ArticlePediatric cardiology2026
Effects of Cardiac Remodeling and Altered Mechanics on Cardiac Outcomes in Fulminant Myocarditis in Children: Insight from a Longitudinal Pilot Study.
Article in Pediatric cardiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- The Utility of Strain Echocardiography in the Diagnosis of Pediatric Myocarditis: A Systematic Review and Meta-Analysis.Echocardiography (Mount Kisco, N.Y.) · 2026Pooled it
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fulminant presentations of acute myocarditis can predict cardiac functional and patient outcomes. This longitudinal study compared pediatric cohorts with fulminant Multisystem Inflammatory Syndrome-related myocarditis (MISCM) vs non-COVID-19 viral myocarditis (VM) to test the hypothesis that the adverse left ventricular (LV) remodeling rather than the phenotype of presentation predicts clinical outcomes. This is a retrospective analysis of 54 children with MISCM (age 6 ± 4 years, weight 32.5 ± 24.6 kg, male 44%) and 26 children with VM (age 3.8 ± 4.8 years, weight 17.7 ± 17.7 kg, male 56%) on hospitalization and one-year follow-up. VM patients exhibited acute LV remodeling, but MISC patients did not (LV end-diastolic dimension z score 2.05 ± 2.50 vs 0.04 ± 1.10, p = 0.00). Compared to the MISCM, VM patients had severe LV systolic and diastolic dysfunction (ejection fraction 54.6% vs 39.9%, four-chamber longitudinal strain - 15.6% vs - 8.7%, and left atrial strain 25.5% vs 13.9% p = 0.000), increased need for mechanical circulatory support (39% vs 7%), 2 mortalities, one cardiac transplant, and stage C heart failure in the 17 survivors at discharge. Ejection fraction normalized but abnormal segmental four-chamber longitudinal strain persisted in both cohorts with most VM patients remaining on anti-failure treatment at one-year follow-up. Inflammation-mediated acute LV remodeling rather than the phenotype of presentation may determine LV function and patient outcomes. Non-invasive imaging can play a useful role in the assessment of the mechanism of LV remodeling and defining the trajectory of LV function and cardiac outcomes.
Indexed as
Identifiers
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Registered trials
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