Evidence map›Paper›PMID 40272468›Full record

ArticleNeuroradiology2025

Jugular bulb ASL-MRI hyperintensity and severe internal jugular vein stenosis: a potential pitfall in neuroimaging.

Thomas R Geisbush, Siddhant S Dhawan, Periakaruppan V Manickam, Tarik F Massoud

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In one paragraph

Article in Neuroradiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Thomas R GeisbushDivision of Neuroimaging and Neurointervention, Department of Radiology, Stanford University School of Medicine, Stanford, USA.ORCID http://orcid.org/0000-0002-7494-5598
Siddhant S DhawanDivision of Neuroimaging and Neurointervention, Department of Radiology, Stanford University School of Medicine, Stanford, USA.ORCID http://orcid.org/0000-0002-2826-955X
Periakaruppan V ManickamDivision of Neuroimaging and Neurointervention, Department of Radiology, Stanford University School of Medicine, Stanford, USA.ORCID http://orcid.org/0000-0001-8112-7174
Tarik F MassoudDivision of Neuroimaging and Neurointervention, Department of Radiology, Stanford University School of Medicine, Stanford, USA. tmassoud@stanford.edu.ORCID http://orcid.org/0000-0002-9694-1408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Incidental artifactual MRI arterial spin-labeling (ASL-MRI) hyperintense signal at the left jugular bulb (JB-ASL[+]) often creates a neurodiagnostic dilemma because of potential misinterpretation as a dural arteriovenous fistula. JB-ASL(+) likely follows 'benign jugular venous reflux' but an additional contribution to signal genesis owing to styloidogenic jugular venous compression (SJVC) has not been evaluated previously. We studied the link between SJVC percentage stenosis of internal jugular veins (IJVs) and JB-ASL(+) signal intensity by retrospectively reviewing MRIs of 30 JB-ASL(+) patients and 30 age and sex-matched JB-ASL(-) controls. In JB-ASL(+) patients, we found a significantly higher percent increase in ASL-MRI hyperintensity with severe (> 75% IJV stenosis) versus non-severe SJVC (p = 0.026). Thus, in some patients, accentuation of JB-ASL(+) signal conceivably occurs after retrograde trapping of labeled venous blood proximal to a severe SJVC. Presence of severe SJVC represents a novel contributory factor in understanding JB-ASL(+) as a clinically problematic source of neuroimaging misdiagnosis.

Indexed as

ArtifactsJugular VeinsMagnetic Resonance AngiographyMagnetic Resonance ImagingNeuroimagingAdultAgedConstriction, PathologicFemaleHumansMaleMiddle AgedRetrospective StudiesSpin LabelsSpin LabelsCentral nervous system vascular malformationsMagnetic resonance imagingSkull base

Identifiers

PMID40272468

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.