ArticleClinical research in cardiology : official journal of the German Cardiac Society2025
Long-term outcome after multiple VT ablations in NICM patients.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Ventricular Tachycardia Ablation in Structural Heart Disease With LVEF > 35%: Clinical Outcomes and Recurrence Patterns.Journal of cardiovascular electrophysiology · 2026Article
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9 authors.
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Abstract
backgroundData about ventricular tachycardia (VT) ablation in patients with non-ischemic cardiomyopathies (NICM) is limited. This study sought to compare the acute and long-term outcomes of VT ablation in different NICMs.
methodsIn this large single-center study consecutive patients presenting with NICM and sustained VTs undergoing VT ablation were included from May 2016 to February 2022. The patients were divided according to underlying NICM and investigated regarding endpoints of VT recurrences and cardiovascular mortality.
resultsA total of 206 patients undergoing a total of 323 VT ablations were included (59 ± 16 years; 81% male; LVEF 36 ± 14%; DCM 57%, myocarditis 26%, sarcoidosis 8%, ARVC 9%). The acute procedural success was highest among ARVC (90%) and lowest among DCM patients (74%). 17% showed in-hospital recurrences (4% clinical VTs) with no difference among different NICMs. DCM patients were discharged with highest rates of antiarrhythmic drugs (41%), whereas ARVC patients with lowest (11%). Long-term VT recurrences during mean follow-up of 38 ± 22 months were highest among DCM patients with 61% followed by myocarditis with 56%, ARVC with 41% and sarcoidosis with 35% (log-rank p = 0.148). The recurrences of clinical VT were present in only 5% of all patients. 52 patients with recurrences (51%) underwent a second procedure with recurrences rates of any VT in 50% (highest among DCM patients; log-rank p = 0.259). 20 patients underwent a 3rd VT ablation, 15 a 4th, 6 a 5th and 1 patient a 6th procedure. Freedom from any VT after multiple procedures were different among etiologies (57% DCM vs. 74% myocarditis vs. 71% sarcoidosis vs. 82% ARVC; log-rank p = 0.067). Cardiovascular mortality was 19% with highest rates among DCM patients (log-rank p = 0.001).
conclusionsVT ablation among patients with NICM is highly effective with sufficient rhythm control in 2/3 of all patients, but non-clinical VT recurrences are common, especially in DCM patients. Those patients reveal highest cardiovascular mortality.
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