ArticleInvestigative ophthalmology & visual science2025
Retinal Structure and Microcirculation Alterations in Patients With Papillary Thyroid Carcinoma: An Optical Coherence Tomography and Angiography Study.
Article in Investigative ophthalmology & visual science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Retinal and Optic-Disc Changes Associated With ¹³¹I Therapy in Papillary Thyroid Carcinoma and Their Determinants.Investigative ophthalmology & visual science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: This study aimed to compare the retinal thickness, vessel density, and perfusion density in patients with papillary thyroid carcinoma (PTC) and healthy controls using optical coherence tomography (OCT) and OCT angiography. And investigating the influence of serological parameters and carcinoma signs with retinal structural and microcirculatory in PTC patients. Methods: This cross-sectional study included 174 PTC patients (345 eyes) and 179 healthy subjects (358 eyes). Serological parameters (complete blood count, thyroid function, and lymphocyte subsets) and retinal thickness and flow parameters were compared between the two groups, and the correlations of retinal parameters with serological parameters in the PTC group. We investigated the effect of carcinoma signs (tumor size, focus location, lymphatic metastasis, surrounding tissue invasion, and BRAF mutations) on retinal parameters. Results: PTC patients exhibited significantly thinner retinal thickness and reduced vessel density and perfusion density in the macular superficial vascular plexus compared with healthy controls. Platelet-to-lymphocyte ratios and thyroglobulin were inversely correlated with retinal parameters, and CD4+ T cells were positively correlated. Aggressive carcinoma signs thicken the retinal thickness more than nonaggressive cases. Conclusions: The findings indicate a trend toward macular thinning and retinal microcirculatory dysfunction in the PTC patients, and these changes may be related to chronic inflammation and immune dysregulation secondary to cancer progression. OCT and OCT angiography show potential as noninvasive tools for detecting subclinical retinal abnormalities in PTC patients, and retinal alterations may serve as a surrogate marker for systemic inflammation. However, further studies are needed to address confounders and establish causality.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.