Evidence map›Paper›PMID 40272356›Full record

ArticleJACC. Basic to translational science2025

Chemokine Receptor 2 Is a Theranostic Biomarker for Abdominal Aortic Aneurysms.

Santiago Elizondo-Benedetto, Sergio Sastriques-Dunlop, Lisa Detering, Batool Arif, Gyu Seong Heo, Deborah Sultan, Hannah Luehmann, Xiaohui Zhang, Xuefeng Gao, Andrea Bredemeyer and 15 more

Abstract read
In one paragraph

Article in JACC. Basic to translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Assessment of CCR2 PET as a Biomarker for Head and Neck Squamous Cell Carcinoma.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Emerging PET radiotracers for vascular imaging.Rheumatology (Oxford, England) · 2025
    Review
  6. Article
  7. Review
  8. Article
  9. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

25 authors.

Santiago Elizondo-BenedettoSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Sergio Sastriques-DunlopSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Lisa DeteringDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Batool ArifSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Gyu Seong HeoDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Deborah SultanDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Hannah LuehmannDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Xiaohui ZhangDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Xuefeng GaoDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Andrea BredemeyerDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Mohamed S ZaghloulSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Kitty HarrisonDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Dakkota ThiesDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Laura McDonaldSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Christophe CombadièreSorbonne Université, INSERM, CNRS, Centre d'Immunologie et des Maladies Infectieuses, Cimi-Paris, Paris, France.
Chieh-Yu LinDepartment of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.
Yeona KangDepartment of Mathematics, Howard University, Washington, DC, USA.
Jie ZhengDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Joseph IppolitoDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Richard LaforestDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Kory LavineDepartment of Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Robert J GroplerDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA.
Sean J EnglishSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Mohamed A ZayedSection of Vascular Surgery, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA; Division of Molecular Cell Biology, Washington University School of Medicine, St. Louis, Missouri, USA; Department of Biomedical Engineering; Washington University School of Medicine, St. Louis, Missouri, USA; Veterans Affairs St. Louis Health Care System, St. Louis, Missouri, USA; Division of Surgical Sciences, Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Yongjian LiuDepartment of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA. Electronic address: yongjianliu@wustl.edu.

Funding

Training/DisseminationP41EB025815 · NIBIB · WASHINGTON UNIVERSITY · PI Robert J. Gropler · 2018 to 2026
$12.7M
Targeted Molecular Probes for Atherosclerosis Imaging and TherapyR35HL145212 · NHLBI · WASHINGTON UNIVERSITY · PI LIU, YONGJIAN · 2019 to 2025
$5.1M
Specification and Function of Tissue Resident and Recruited Macrophages in Cardiac Remodeling and Heart FailureR35HL161185 · NHLBI · WASHINGTON UNIVERSITY · PI Kory J. Lavine · 2022 to 2026
$4.3M
Pediatric Cardiovascular and Pulmonary Research Training Program.T32HL125241 · NHLBI · WASHINGTON UNIVERSITY · PI Juliane Bubeck Wardenburg, Kory J. Lavine · 2015 to 2026
$4.1M
PET Detection of CCR2 in Human AtherosclerosisR01HL150891 · NHLBI · WASHINGTON UNIVERSITY · PI GROPLER, ROBERT J., WOODARD, PAMELA K · 2020 to 2024
$3.7M
Training OPportunities in Translational Imaging Education and Research (TOP-TIER)T32EB021955 · NIBIB · WASHINGTON UNIVERSITY · PI Hongyu An, Joseph Edward Ippolito · 2017 to 2026
$2.4M
NHLBI NIH HHS R01 HL150891NHLBI NIH HHS R35 HL145212NHLBI NIH HHS R35 HL161185NHLBI NIH HHS T32 HL125241NIBIB NIH HHS P41 EB025815NIBIB NIH HHS T32 EB021955
6 · The paper itself

Abstract

Abdominal aortic aneurysm (AAA) is a degenerative vascular disease with a high mortality upon rupture. There is no diagnosis to predict the rupture nor effective medical therapies to prevent rupture. Here we demonstrate that the C-C chemokine receptor type 2 (CCR2) is a theranostic biomarker for AAA. In rat AAA models, we determined the potential of a CCR2-targeted positron emission tomography radiotracer [

Indexed as

abdominal aortic aneurysmCCR2inflammationtheranostictranslation

Identifiers

PMID40272356
PMCPMC12434256

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.