Evidence map›Paper›PMID 40272178›Full record

ArticleApplied and environmental microbiology2025

Genetic and phenotypic stability of

Laura Brunelli, Susanna Perotti, Giorgio Gargari, Valerio De Vitis, Giacomo Mantegazza, Roberto Ferrari, Mario Minuzzo, Elena Pierallini, Giovanni Ricci, Walter Fiore and 1 more

Abstract read
In one paragraph

Article in Applied and environmental microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Genomic characterization ofApplied and environmental microbiology · 2026
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Laura Brunelli *Alfasigma S.p.A., Milan, Italy.
Susanna Perotti *Department of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Giorgio GargariDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Valerio De VitisAlfasigma S.p.A., Milan, Italy.
Giacomo MantegazzaDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Roberto FerrariAlfasigma S.p.A., Milan, Italy.
Mario MinuzzoAlfasigma S.p.A., Milan, Italy.
Elena PieralliniDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Giovanni RicciDepartment of Food, Environmental and Nutritional Sciences (DeFENS), University of Milan, Milan, Italy.
Walter FioreAlfasigma S.p.A., Milan, Italy.
Simone GuglielmettiμbEat lab, Department of Biotechnology and Biosciences, University of Milano-Bicocca, Milan, Italy.ORCID 0000-0002-8673-8190

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The commercialization of a probiotic microorganism requires genetic and phenotypic consistency across production lots. However, the large-scale industrial production of probiotic microbial biomasses over years poses a risk of genetic drift, potentially affecting the probiotic's ability to confer health benefits. This study assessed the stability of

Indexed as

Industrial MicrobiologyLacticaseibacillus paracaseiProbioticsFecesGenome, BacterialHumansPhenotypeCaco-2complete genomegenetic driftINFOGESTL. casei DGPacBioprobiotic

Identifiers

PMID40272178
PMCPMC12093954

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.