ArticleJournal of cosmetic dermatology2025
Combination of Botulinum Toxin A and Hyaluronic Acid Improved Facial Pore Enlargement Caused by Acne.
Article in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A Holistic Skin Management Approach of CTMP Improved Skin Texture in Patient With Acne Scarring: A Case Report.Clinical case reports · 2026Article
- Advances in Bioprinting to Model Immune-Mediated Skin Diseases.Advanced healthcare materials · 2026Review
- Exploring the Therapeutic Potential of Botulinum Toxin in Treating Post-Acne Sequelae: A Critical Review.Clinical, cosmetic and investigational dermatology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcne often leads to enlarged pores on the facial skin, seriously affecting the patient's appearance. Topical and oral medications have poor efficacy in some cases of severe pore enlargement.
objectiveThis study aimed to explore the clinical efficacy and safety of botulinum toxin A combined with hyaluronic acid in improving facial pore enlargement.
methodA retrospective study was conducted on 40 acne patients with enlarged pores. Botulinum toxin A and non-cross-linked hyaluronic acid compound were injected into the patient's face using mesotherapy with nine 32-gauge microneedles. VISIA was used to record the conditions of facial pores, texture, and porphyrins. The physician's assessment of the improvement score and the patient satisfaction evaluation are used to evaluate the treatment effect.
resultOne month after treatment, the combination of botulinum toxin and non-cross-linked hyaluronic acid compound significantly improved facial pore enlargement. Although the effects decreased, the conditions of facial pores, texture, and porphyrins 4 months after treatment still had a significant difference from those at baseline.
conclusionThe combination of botulinum toxin A and non-cross-linked hyaluronic acid compound is safe and effective in treating enlarged pores, indicating its promotional value.
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Registered trials
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