Evidence map›Paper›PMID 40271961›Full record

Trial reportJournal of hospital medicine2025

Intervention for hospitalized people with chronic pain and elevated risk for opioid-related harm: A pilot randomized controlled trial.

Melissa B Weimer, Michele J Buonora, Alexandra M Hajduk, Adam L Ackerman, Krishna R Daggula, William C Becker, Sarwat I Chaudhry, David A Fiellin

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Journal of hospital medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Melissa B WeimerSection of General Internal Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.ORCID http://orcid.org/0000-0002-5624-2434
Michele J BuonoraNational Clinician Scholars Program, Yale School of Medicine, New Haven, Connecticut, USA.
Alexandra M HajdukSection of Geriatrics, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Adam L AckermanSection of General Internal Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Krishna R DaggulaJoint Data Analytics Team, Yale New Haven Health System, New Haven, Connecticut, USA.
William C BeckerSection of General Internal Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
Sarwat I ChaudhrySection of General Internal Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.
David A FiellinSection of General Internal Medicine, Department of Medicine, Yale School of Medicine, New Haven, Connecticut, USA.

Funding

HEAL Initiative: Integrative Management of chronic Pain and OUD for Whole Recovery (IMPOWR): Research CentersRM1DA055310 · NIDA · YALE UNIVERSITY · PI BARRY, DECLAN T., BECKER, WILLIAM C · 2021 to 2025
$12.9M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
CLC NIH HHS 1RM1DA055310Helping to End Addiction Long-term® Initiative 1RM1DA055310Integrative Management of chronic Pain and OUD for Whole Recovery: Yale and Organizations UnitedNational Center for Advancing Translational Science (NCATS)National Institutes of Health (NIH)NCATS NIH HHS TL1 TR001864NIDA NIH HHS RM1 DA055310Yale National Clinician Scholars Program CTSA Grant Number TL1 TR001864
6 · The paper itself

Abstract

backgroundThe management of analgesia in people hospitalized with chronic pain and elevated risk for opioid-related harm is challenging. While opioid stewardship programs could provide guidance, their feasibility in this population has not been examined.

objectivesTo develop a case identification tool and evaluate the feasibility of an electronic medical record (EMR)-delivered opioid stewardship and pain intervention among hospitalized people with chronic pain and elevated risk for opioid-related harm.

methodsAfter developing and evaluating the operating characteristics of a case identification tool to identify people with chronic pain and elevated risk for opioid-related harm, hospitalized adults with chronic pain and elevated risk for opioid-related harm were randomized to an EMR-delivered opioid stewardship and pain intervention versus usual care. Primary outcomes were feasibility-based. Exploratory outcomes were pain-related clinical outcomes.

resultsThe case identification tool had a sensitivity of 88.9% and a specificity of 95.7%. The trial recruited 52/97 (54%) of potential participants who completed 52/52 (100%) potential assessments and of whom 45/52 (87%) were retained in the study at 4 weeks, demonstrating feasibility. On average, both treatment arms received 56% of the recommended guideline-concordant care and there was no significant difference in opioid and pain-related care in the two groups.

conclusionIt is both feasible to develop an EMR-based tool to prospectively identify hospitalized people with chronic pain and elevated risk for opioid-related harm as well as recruit these individuals to an EMR-delivered opioid stewardship and pain intervention. Additional strategies to support the provision of guideline-concordant care may be warranted.

Indexed as

Analgesics, OpioidChronic PainHospitalizationOpioid-Related DisordersPain ManagementAdultAgedElectronic Health RecordsFeasibility StudiesFemaleHumansMaleMiddle AgedPilot ProjectsAnalgesics, Opioid

Identifiers

PMID40271961
PMCPMC12354179

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.