ArticleAvicenna journal of phytomedicine
Regulation of the microRNA profiles related to Myh7 and Myh6 in myocardial ischemia through proanthocyanidins and different intensity exercise training.
Article in Avicenna journal of phytomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: Myocardial ischemia (MI) and circulatory arrest are associated with unfavorable cardiovascular outcomes. This study aims to investigate the effects of proanthocyanidins (PC) and regular exercise with various intensity training protocols (low, moderate, and high) on cardiac protection in a rat model of MI induced by isoproterenol. Materials and Methods: Based on bioinformatics, a pool of microRNAs and mRNAs was assessed according to significant differential expression in MI condition. Further, the networks of hub genes and mRNA-microRNAs were constructed. After 14 weeks of low, moderate, and high-intensity interval training and oral administration of 300 mg/kg of PC, MI was established in the rats by injecting isoproterenol. The real-time qPCR assessed the relative expressions. Results: Based on the Conclusion: Here, the data indicated that the HIIT protocol could have an effective strategy compared to low-intensity interval training (LIIT) and moderate-intensity interval training protocols (MIIT). Furthermore, HIIT and PC might have protective effects on the MI condition.
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