Evidence map›Paper›PMID 40271476›Full record

ReviewCraniomaxillofacial trauma & reconstruction2025

Obstructive Sleep Apnea Following Secondary Velopharyngeal Insufficiency in Children with Non-Syndromic Cleft Palate: A Systematic Review.

Milton Chin, Mona Haj, Sarah L Versnel, Henriette H W de Gier, Eppo B Wolvius

Abstract readReview
In one paragraph

Review in Craniomaxillofacial trauma & reconstruction, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Milton ChinDepartment of Maxillofacial Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.ORCID https://orcid.org/0009-0003-4516-7541
Mona HajDepartment of Maxillofacial Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Sarah L VersnelDepartment of Plastic and Reconstructive Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Henriette H W de GierDepartment of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.
Eppo B WolviusDepartment of Maxillofacial Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

designSystematic review.

objectiveObstructive sleep apnea (OSA) is a possible complication following secondary velopharyngeal insufficiency surgery in patients with repaired cleft palate. Various surgical techniques are used to treat secondary velopharyngeal insufficiency after cleft palate repair, but the optimal procedure remains debatable. This review provides an overview of the incidence of airway obstructive outcomes related to different surgical modalities.

methodsA systematic search was performed on the 1st of February following the PRISMA guidelines and registered on PROSPERO (CRD42022299715). The following databases were reviewed: Medline, EMBASE, Web of Science, Google Scholar, and the Cochrane Library databases. Studies that included data on the occurrence of OSA following velopharyngeal surgery in children with a repaired non-syndromic cleft palate were included. Non-English articles and studies that included syndromic cleft palate patients were excluded.

resultsTwenty-eight articles met the inclusion criteria. The surgical procedures are classified into three groups: pharyngeal flap procedure (PF), sphincter pharyngoplasty (SP), and palatal muscle repositioning (PMR). Incidence of post-operative OSA and symptoms of OSA were lowest after PMR compared to SP and PF (3%; 34%; 29%, respectively). Pharyngeal flap procedures resulted in the best speech outcomes.

conclusionsPMR results in fewer postoperative complications in terms of OSA and achieves a satisfactory reduction in hypernasal speech. PF procedure carries a higher risk of developing OSA postoperatively but seems to be superior in the reduction in hypernasality.

Indexed as

cleft palateobstructive*/etiologyobstructive sleep apneapharynxsleep apneavelopharyngeal insufficiency

Identifiers

PMID40271476
PMCPMC11995821

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.