ArticleFrontiers in nutrition2025
Higher dietary vitamin D intake influences brain and mental function in elderly Americans: a cross-sectional analysis.
Article in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Vitamin D deficiency and disease conditions relevant to: Orthopaedic translation.Journal of orthopaedic translation · 2026Review
- Impact of Vitamin D Status and Supplementation on Brain-Derived Neurotrophic Factor and Mood-Cognitive Outcomes: A Structured Narrative Review.Nutrients · 2025Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vitamin D is known to have a potential impact on cognitive function and mental health. This study aims to assess the association between dietary vitamin D intake and cognitive performance, as well as depression, in an elderly U.S. population. Methods: Data from the National Health and Nutrition Examination Survey (NHANES) 2013-2014 were analyzed. A total of 1,344 elderly participants were categorized into three tertiles based on their dietary vitamin D intake (D2 + D3). Cognitive function was measured using the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test, Digit Symbol Substitution Test (DSST), and Animal Fluency Test, while depression was assessed through the Patient Health Questionnaire-9 (PHQ-9). Adjustments were made for confounding variables, including age, sex, race, education, physical activity level, and other dietary factors. Results: After adjustment for confounders, individuals in the 3rd tertile of vitamin D intake (≥4.9 mcg/day) had significantly reduced odds of low performance on the CERAD test (OR: 0.77, 95% CI: 0.57-0.98; Conclusion: Our findings suggest that dietary vitamin D intake is associated with improved cognitive function and depressive symptoms in elderly individuals. However, further longitudinal studies are needed to establish causality and explore the underlying mechanisms.
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