ArticleCureus2025
Over-the-Counter Ibuprofen-Induced Pre-Pyloric Gastric Perforation in a 28-Month-Old Child: A Rare Pediatric Case.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Gastric perforation is a rare but potentially life-threatening cause of acute abdomen in pediatric patients beyond the neonatal period. Over-the-counter ibuprofen, often administered without physician oversight, can exacerbate gastric mucosal injury, particularly when used concurrently with corticosteroids. We describe the case of a 28-month-old male with bronchial asthma who developed acute epigastric pain, vomiting, and low-grade fever after receiving four doses of over-the-counter ibuprofen alongside prescribed oral steroids. Abdominal examination and investigations revealed generalized tenderness, elevated inflammatory markers, and pneumoperitoneum on radiographs. Diagnostic laparoscopy identified a pre-pyloric gastric perforation; however, tissue friability necessitated laparotomy and Graham patch repair. Postoperative recovery was uneventful, and further evaluation excluded hypergastrinemia and
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