ArticleInfection and drug resistance2025
Validation of Senescence of the Role of ATM/P53 Pathway in Myocardial Senescence in Mice with Sepsis.
Article in Infection and drug resistance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Acyl-CoA-binding protein (ACBP): a poor-prognosis biomarker in sepsis and a target for disease mitigation.Signal transduction and targeted therapy · 2026Article
- Cancer and aging: complex associations and therapeutic targets.Molecular biomedicine · 2026Review
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Sepsis induces multi-organ damage, including myocardial dysfunction, which is often reversible. However, the role of cell senescence in sepsis-induced myocardial dysfunction (SIMD) remains understudied. This study aimed to investigate gene expression changes related to myocardial aging in sepsis. Methods: Transcriptomic datasets (GSE79962 and GSE141864) were analyzed to identify senescence-related genes (SRGs) by intersecting differentially expressed genes (DEGs) with the CellAge database. Functional enrichment and protein-protein interaction (PPI) network analysis were performed to identify key pathways and hub genes. A murine sepsis model was established via intraperitoneal lipopolysaccharide (LPS) injection, and the Ataxia Telangiectasia Mutated Protein (ATM) inhibitor KU60019 was used to assess the effects on cardiac function and cellular aging. Results: Bioinformatics analysis revealed 15 aging-related genes, including Conclusion: Cellular senescence and immune dysregulation play critical roles in SIMD. Targeting DDR pathways, as demonstrated by KU60019 treatment, provides novel insights into the role of cellular senescence in severe sepsis and its potential therapeutic implications for improving cardiovascular prognosis in septic patients.
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