Evidence map›Paper›PMID 40271117›Full record

ArticleFrontiers in neurology2025

Effects of low-intensity pulsed focal ultrasound-mediated delivery of endothelial progenitor-derived exosomes in tMCAo stroke.

Ahmet Alptekin, Mohammad B Khan, Mahrima Parvin, Hasanul Chowdhury, Sawaiz Kashif, Fowzia A Selina, Anika Bushra, Justin Kelleher, Santu Ghosh, Dylan Williams and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Ahmet AlptekinTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Mohammad B KhanDepartment of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Mahrima ParvinTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Hasanul ChowdhuryTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Sawaiz KashifTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Fowzia A SelinaTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Anika BushraTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Justin KelleherTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Santu GhoshDepartment of Biostatistics, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Dylan WilliamsDepartment of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Emily BlumlingDepartment of Neurology, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Roxan AraSmall Animal Imaging Core, GCC, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Asamoah BosomtwiSmall Animal Imaging Core, GCC, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Joseph A FrankLaboratory of Diagnostic Radiology Research, Clinical Center, National Institutes of Health, Bethesda, MD, United States.
Krishnan M DhandapaniDepartment of Neurosurgery, Medical College of Georgia, Augusta University, Augusta, GA, United States.
Ali S ArbabTumor Angiogenesis Laboratory, GCC, Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, United States.

Funding

Augusta SPAN 2U01NS130590 · NINDS · AUGUSTA UNIVERSITY · PI DHANDAPANI, KRISHNAN M., HESS, DAVID C. · 2023 to 2025
$1.8M
Application of pulsed focused ultrasound (pFUS) to deliver engineered therapeutic exosomes for the treatment of ischemic strokeR21NS130443 · NINDS · AUGUSTA UNIVERSITY · PI ARBAB, ALI SYED · 2023 to 2023
$424k
NINDS NIH HHS R21 NS130443NINDS NIH HHS U01 NS130590
6 · The paper itself

Abstract

Introduction: Exosomes from different sources have been used for therapeutic purposes to target stroke and other disorders. However, exosomes from endothelial progenitor cells (EPCs) have not been tested in any stroke model, and Methods: To enhance exosome delivery to the stroke area, we utilized LIPFUS. We evaluated stroke volume using MRI at different time points and conducted behavioral studies parallel to MRI to determine recovery. Ultimately, we studied brain tissue using immunohistochemistry to assess the extent of stroke and tissue regeneration. Results and Discussion:

Indexed as

exosomesischemic strokelow-intensity-pulsed focused ultrasound (LIPFUS)magnetic resonance imaging (MRI)single photon emission computed tomography (SPECT)

Identifiers

PMID40271117
PMCPMC12014438

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.