SynthesisFrontiers in neurology2025
Coordinates-based meta-analysis for vestibular migraine and the underlying mechanisms behind it.
Synthesis in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Vestibular cortex-related effective connectivity signatures: characterization and differentiation of vestibular migraine patients via magnetic resonance imaging and machine learning.The journal of headache and pain · 2026Article
- Imaging of vestibular function and disorders and its clinical relevance.Current opinion in neurology · 2026Review
- Vestibular migraine. Clinical and diagnostic challenges, and emerging therapeutic approaches.Current opinion in neurology · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Vestibular migraine (VM) is a leading cause of recurrent vertigo episodes. Voxel-based morphometry (VBM) is a reliable technique to analyze structural changes, particularly in gray matter (GM) volume, across various neurological conditions. Despite the growing amount of neuroimaging data in recent decades, a comprehensive review of GM alterations in VM remains lacking. Methods: We conducted a systematic review of three English-language databases (PubMed, Embase, and Web of Science) and two Chinese-language databases (China National Knowledge Infrastructure and Wanfang) to evaluate existing neuroimaging data on GM volume in VM patients. A coordinate-based meta-analysis (CBMA) was performed using the latest algorithm, seed-based d mapping with permutation of subject images (SDM-PSI), to identify brain alterations across individual studies. Results: Five studies (103 VM patients, 107 HCs) were included. The CBMA demonstrated a significant reduction in GM volume in VM patients compared to HCs, with peak convergence in the left rolandic operculum (SDM-Z = -3.68, Conclusion: This meta-analysis confirms reliable GM volume alterations in the posterior insula-operculum region of VM patients. Longitudinal studies with standardized imaging protocols are needed to clarify whether these changes are causes or consequences of VM. Systematic review registration: https://www.crd.york.ac.uk/prospero/, identifier CRD42021277684.
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