ArticleFrontiers in pharmacology2025
Umbilical cord stem cells therapy against bacterial pneumonia based on zebrafish pneumonia model.
Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The increasing incidence and mortality rates of respiratory system diseases globally pose a significant public health challenge. Bacterial pneumonia is one of the leading risk factors for acute lung injury. Conventional antibiotics face inherent limitations, particularly the increase in bacterial resistance and inability to suppress inflammatory states, underscoring the urgent need for novel approaches to combat bacterial pneumonia. Methods: This study evaluated the therapeutic effects of umbilical cord mesenchymal stem cells (UC-MSCs) on bacterial pneumonia in a zebrafish model, focusing on their impact on macrophage and neutrophil counts and their inhibitory effects on Results: Our study found that UC-MSCs can effectively inhibit the development of bacterial pneumonia, primarily by reducing the number of macrophages and neutrophils and inhibiting the secretion of inflammatory factors IL-1β, IL-6, and TNF-α, thereby suppressing Conclusion: UC-MSCs demonstrate promising potential in the treatment of bacterial pneumonia. This study provides important reference for the therapeutic effects and mechanisms of stem cell treatment of bacterial pneumonia, offering new avenues for clinical applications.
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