ArticleChemical science2025
Enhancing fluorescent probe design through multilayer interaction convolutional networks: advancing biosensing and bioimaging precision.
Article in Chemical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Nanoprobe-Enabled Precision Imaging and Panoramic Boundary Delineation in Retinoblastoma.Cancer innovation · 2026Review
- Enzyme-Activatable Fluorogenic Probes: Design Strategies, Biomedical Applications, and Future Perspectives.Journal of the American Chemical Society · 2026Review
- Review: structural determinants of organic dyes for controlling biological clearance pathways.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescent probes are pivotal in biosensing and bioimaging, necessitating precise spectral tailoring for high-performance applications. Despite their importance, probe design remains largely empirical, a process that is both time-consuming and laborious. To streamline this, we created a comprehensive dataset of over 600 rhodamine fluorescent probes and employed a multilayer interaction convolutional model (MICNet) trained on molecular fingerprints to accurately predict excitation and emission wavelengths. Our model demonstrated high accuracy with mean relative errors (MRE) of 0.1% for excitation and 0.4% for emission wavelengths. Advancing this, we implemented a closed-loop strategy that integrates experimental feedback to iteratively enhance the design algorithm's accuracy, thereby improving the probes' performance and reliability. This method not only accelerates the probe development cycle but also facilitates the creation of spectrally customized fluorescent probes, offering a significant advancement in the field of bioanalytical chemistry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.