ArticleiScience2025
Perivascular cerebrospinal fluid inflow matches interstitial fluid efflux in anesthetized rats.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Glymphatic system impairment in neurological disorders: potential mechanisms and therapeutic targets.Molecular biomedicine · 2026Review
- Quantitative assessment of flow between cerebrospinal and interstitial fluid compartments in humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Vessel-Resolved Mapping of Perivascular Spaces Reveals Hierarchical Neurofluid OrganizationbioRxiv : the preprint server for biology · 2026Article
- An implantable dual-chamber capsule with three release modes for site-specific delivery and enhanced therapeutic efficacy.iScience · 2026Article
- Quantifying cerebrospinal fluid flow in pial perivascular spaces of rats.Fluids and barriers of the CNS · 2026Article
- Cerebrospinal fluid mechanics across CNS barriers: from production, circulation, and clearance to mechanomedicine.Frontiers in neuroscience · 2026Review
- The Fluidic Connectome in Brain Disease: Integrating Aquaporin-4 Polarity with Multisystem Pathways in Neurodegeneration.International journal of molecular sciences · 2025Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Waste solutes are cleared from the brain via outflow of interstitial fluid (ISF). Blood-brain barrier (BBB) water secretion and inflow of cerebrospinal fluid (CSF) via perivascular channels have been suggested as potential fluid sources to replace outflowing ISF. To assess the role of CSF inflow in brain clearance, we measured both CSF inflow and ISF outflow in ketamine/dexmedetomidine anesthetized rats. We used magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) to track tracer flows after infusion in CSF or ISF. CSF inflow was estimated at 0.5-0.7 μL g
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.