ArticleJCEM case reports2025
Pseudo-Malabsorption in High Dose Levothyroxine-Resistant Hypothyroidism.
Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
A 38-year-old woman was diagnosed with hypothyroidism during pregnancy at age 35 years and started on levothyroxine (LT4). Despite increasing the dose to 400 μg/day and adding liothyronine, her thyroid function did not improve, leading to hospitalization. Upon admission, her thyroid-stimulating hormone (TSH), free triiodothyronine (T3), and free thyroxine (T4) levels were 255 μIU/mL (255 mIU/L) (reference range [RR]: 0.35---4.94 μIU/mL; 0.35---4.94 mIU/L), 3.42 pg/mL (5.27 pmol/L) (RR: 1.71-3.71 pg/mL; 2.63-5.70 pmol/L), and 0.153 ng/dL (1.97 pmol/L) (RR: 0.70-1.48 ng/dL; 9.01-19.05 pmol/L), respectively. She reported good adherence to medication and not consuming interfering food or medication. Endoscopic examination revealed no malabsorption. A 1000-μg oral LT4 loading test showed an increase in free T4 level from 0.787 (10.1 pmol/L) to 2.40 ng/dL (30.9 pmol/L), indicating pseudo-malabsorption. After presenting the loading test results, she admitted to nonadherence. A multidisciplinary team intervened, conducting individual counseling and simplifying treatment. Post-discharge, with LT4 200 μg/day, her TSH, free T3, and free T4 levels improved to 0.496 μIU/mL (0.496 mIU/L), 5.23 pg/mL (8.05 pmol/L), and 2.19 ng/dL (28.2 pmol/L), respectively. When addressing treatment-resistant hypothyroidism, it is crucial to evaluate patient history and medication schedule and to check for malabsorption. Comprehensive interventions are recommended if nonadherence is suspected.
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