Evidence map›Paper›PMID 40270997›Full record

ArticleJCEM case reports2025

Efficacy of Sirolimus in Treating Refractory Lymphatic Malformation in Noonan Syndrome: A Case Study.

Yuka Nakajima, Yoh Watanabe, Kohei Iwata, Yuki Yamada, Shinji Higuchi, Jun Mori

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in JCEM case reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Clinical consensus guidelines for the management of Noonan syndrome in Japan.Clinical pediatric endocrinology : case reports and clinical investigations : official journal of the Japanese Society for Pediatric Endocrinology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yuka NakajimaDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.ORCID https://orcid.org/0009-0006-8331-7370
Yoh WatanabeDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.ORCID https://orcid.org/0009-0006-9643-7566
Kohei IwataDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.ORCID https://orcid.org/0009-0007-2836-0971
Yuki YamadaDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.ORCID https://orcid.org/0009-0008-2601-7157
Shinji HiguchiDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.ORCID https://orcid.org/0000-0002-9461-9909
Jun MoriDivision of Pediatric Endocrinology, Metabolism and Nephrology, Children's Medical Center, Osaka City General Hospital, Osaka 534-0021, Japan.ORCID https://orcid.org/0000-0002-1271-1577

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A female patient with Noonan syndrome, attributed to a pathogenic

Indexed as

chyle dischargelymphatic abnormalitiesNoonan syndromesirolimus

Identifiers

PMID40270997
PMCPMC12015159

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.