Trial reportDrug design, development and therapy2025
Young, Healthy, Underweight Women Require Higher Effective Doses of Propofol for Successful Gastroscope Insertion: a Dose-Finding Study Using Dixon's Up-and-Down Method.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- ECDrug design, development and therapy · 2026Trial
- Investigating Effective Application Times for Topical Anesthetics in Non-Coring Needle Insertion Over Totally Implantable Venous Access Devices.Drug design, development and therapy · 2025Trial
- Article
- Impact of Body Weight on Sedation-Related Outcomes in Complex Electrophysiological Interventions.Healthcare (Basel, Switzerland) · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The number of young women undergoing painless gastroscopy is rising annually. However, the lack of studies on the effective doses of propofol sedation for young, underweight women, presents a clinical challenge. Our study aimed to determine and compare the effective doses of propofol required for successful gastroscope insertion in normal-weight and underweight young women. Patients and Methods: Chinese women aged 18-35 years who were of normal weight (18.5 ≤ body mass index (BMI) < 25 kg/m²) or underweight (BMI < 18.5 kg/m²) and were undergoing painless gastroscopy were included. The initial induction dose of propofol was 2.0 mg/kg, and subsequent doses were adjusted using the modified Dixon's up-and-down method (step size: 0.1 mg/kg). The 50% and 95% effective dose of propofol (ED Results: Thirty patients were included in each group. The modified Dixon's up-and-down method was used, and the ED Conclusion: Young, healthy, underweight women require higher effective doses of propofol for deep sedation for successful gastroscope insertion compared with young, healthy, normal-weight women.
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