ArticleJournal of asthma and allergy2025
Serum miR-130a-3p and miR-326: Correlation with Airway Inflammation and Prognostic Implications in Pediatric Bronchial Asthma.
Article in Journal of asthma and allergy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Multi-omics identifies severe asthma endotypes linked toThe World Allergy Organization journal · 2025Article
- Article
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Authors and funding
3 authors.
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Abstract
Objective: To investigate the relationship between serum microRNA (miR)-130a-3p, miR-326 and airway inflammation in children suffering from bronchial asthma. Methods: A retrospective study was conducted on 122 children suffering from bronchial asthma. According to the disease progression, 122 cases were divided into a remission group of 73 cases and an attack group of 49 cases. Total 50 healthy children received physical examinations during the same period were taken as the control group. These cases were graded as a well-controlled group of 91 cases and a poorly controlled group of 31 cases following 8 weeks of symptomatic treatment. The interaction was analyzed using a multiplication model (by calculating the odds ratio and other indicators of the occurrence of outcomes under different combinations of factor exposures). ROC curve was used to analyze the predictive value. Multivariate Logistic regression was used to analyze the influencing factors. Results: Serum miR-130a-3p and miR-326 levels were negatively correlated with serum IL-4, TGF-β1 and CKLF-1 levels (all Conclusion: The decreased levels of serum miR-130a-3p and miR-326 were related to airway inflammation in children with bronchial asthma. The interaction between the two miRNAs may increase the risk of poor prognosis in children. Detection of the two miRNAs can provide important reference for clinicians to judge the prognosis of children.
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