ArticleACS catalysis2025
Microfluidic Photocatalytic Ring Expansion of Sulfonium Salts for the Synthesis of Cyclic Sulfides.
Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Thiophene Derivatives as Versatile Precursors for (Hetero)Arene and Natural Product Synthesis.Angewandte Chemie (International ed. in English) · 2026Review
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Authors and funding
6 authors.
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Abstract
Cyclic sulfides are relevant building blocks in medicinal and synthetic chemistry, with applications ranging from drug discovery to materials science. However, the synthesis of medium-sized cyclic sulfides (6-8-membered rings) remains largely underdeveloped. Herein, we report a photocatalytic ring-expansion strategy for sulfonium salts, granting access to six-, seven-, and eight-membered cyclic sulfides with very high regio- and diastereocontrol. The implementation of the method under continuous flow was key to increasing the efficiency and minimizing product decomposition. Mechanistic investigations revealed the formation of benzylic radicals and carbocation intermediates that control the high regio- and diastereoselectivity observed. Finally, the synthetic utility of this approach was demonstrated in the synthesis of cyclic sulfoxides and sulfones, which can be easily obtained from the corresponding sulfide products.
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