Evidence map›Paper›PMID 40270884›Full record

ArticleACS catalysis2025

Exploring the Increased Activity of the Blue Light-Dependent Photoenzyme Fatty Acid Photodecarboxylase under Violet Light.

Harry J Spacey, Daniel Healy, Jason M D Kalapothakis, Junfeng Ma, Michiyo Sakuma, Perdita E Barran, Derren J Heyes, Nigel S Scrutton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Harry J SpaceyManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Daniel HealyManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.ORCID https://orcid.org/0000-0001-7845-0499
Jason M D KalapothakisManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Junfeng MaManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Michiyo SakumaManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.
Perdita E BarranManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.ORCID https://orcid.org/0000-0002-7720-586X
Derren J HeyesManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.ORCID https://orcid.org/0000-0002-7453-1571
Nigel S ScruttonManchester Institute of Biotechnology, University of Manchester, 131 Princess Street, Manchester M1 7DN, U.K.ORCID https://orcid.org/0000-0002-4182-3500

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatty acid photodecarboxylase (FAP) is a FAD-containing enzyme that catalyzes the light-driven decarboxylation of medium-long chain fatty acids. Over recent years, the substrate scope of FAP has been broadened to improve its potential to catalyze a range of blue light-dependent industrially relevant reactions. However, photoinactivation constitutes a major hurdle for generalized applications. Previous studies have suggested that violet light may be a more suitable illumination wavelength for many of these applications. Here, we have investigated any possible enhancement in the catalytic activity of FAP upon illumination with violet light and utilized a spectrophotometric assay that detects the production of CO

Identifiers

PMID40270884
PMCPMC12012757

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.