ReviewACS catalysis2025
Unconventional Parahydrogen-Induced Hyperpolarization Effects in Chemistry and Catalysis: From Photoreactions to Enzymes.
Review in ACS catalysis, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Hyperpolarization of PyridineAngewandte Chemie (International ed. in English) · 2026Article
- Biocompatible SABRE Hyperpolarization of [1-Chemistry (Weinheim an der Bergstrasse, Germany) · 2026Article
- Intermolecular Nuclear Spin Hyperpolarization Transfer via Cross-Relaxation Triggers RASER of Solute Molecules.Angewandte Chemie (International ed. in English) · 2026Article
- Why Fundamental Research Matters: Lessons from Nuclear Magnetic Resonance.ACS central science · 2026Article
- Probing Hydrogen Activation in a Dimetal Dihydride Complex by Symmetric Exchange with Parahydrogen.Journal of the American Chemical Society · 2026Article
- Upscaling the Hyperpolarization Sample Volume of an Automated Hydrogenative Parahydrogen-Induced Polarizer.ACS measurement science au · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nuclear spin hyperpolarization utilizing parahydrogen has the potential for broad applications in chemistry, catalysis, biochemistry, and medicine. This review examines recent chemical and biochemical insights gained using parahydrogen-induced polarization (PHIP). We begin with photoinduced PHIP, which allows the investigation of short-lived and photoactivated catalysis. Next, we review the partially negative line effect, in which distinctive line shape helps to reveal information about rapid exchange with parahydrogen and the role of short-lived catalytic species. The NMR signal enhancement of a single proton in oneH-PHIP is discussed, challenging the underpinning concept of the necessity of pairwise hydrogenation. Furthermore, we examine metal-free PHIP facilitated by frustrated Lewis pair molecular tweezers and radicaloids, demonstrating alternative routes to hydrogenation. Although symmetric molecules incorporating parahydrogen are NMR silent, we showcase methods that reveal hyperpolarized states through post-hydrogenation reactions. We discuss chemical exchange processes that mediate polarization transfer between parahydrogen and a molecular target, expanding the reach of PHIP without synthesizing specialized precursors. We conclude this review by highlighting the role of PHIP in uncovering the H
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.