Evidence map›Paper›PMID 40270825›Full record

ArticleFrontiers in microbiology2025

Advancing syphilis diagnosis: multi-phase study evaluation of a TpN17-based double-antigen sandwich ELISA for detecting

Ângelo Antônio Oliveira Silva, Larissa Carvalho Medrado Vasconcelos, Natália Erdens Maron Freitas, Talita Andrade Oliva, Miralba Freire Carvalho Ribeiro Silva, Isadora Cristina Siqueira, Edimilson Domingos Silva, Keila Gisele Azevedo Figueiredo Santos, Maria Amélia Virgens Lima, Nilson Ivo Tonin Zanchin and 1 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Double-antigen sandwich ELISA based on chimeric antigens for detection of antibodies to Trypanosoma cruzi in human sera - A phase II study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Ângelo Antônio Oliveira SilvaAdvanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador, Brazil.
Larissa Carvalho Medrado VasconcelosAdvanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador, Brazil.
Natália Erdens Maron FreitasAdvanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador, Brazil.
Talita Andrade OlivaState Center for Diagnosis, Assistance, and Research (CEDAP), Bahia State Health Department (SESAB), Salvador, Brazil.
Miralba Freire Carvalho Ribeiro SilvaState Center for Diagnosis, Assistance, and Research (CEDAP), Bahia State Health Department (SESAB), Salvador, Brazil.
Isadora Cristina SiqueiraInterdisciplinary Research Group in Biotechnology and Epidemiology of Infectious Diseases (GRUPIBE), Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ-BA), Salvador, Brazil.
Edimilson Domingos SilvaDiagnostic Technology Laboratory, Immunobiological Technology Institute (Bio-Manguinhos), Oswaldo Cruz Foundation (Fiocruz-RJ), Rio de Janeiro, Brazil.
Keila Gisele Azevedo Figueiredo SantosDiagnostic Technology Laboratory, Immunobiological Technology Institute (Bio-Manguinhos), Oswaldo Cruz Foundation (Fiocruz-RJ), Rio de Janeiro, Brazil.
Maria Amélia Virgens LimaDiagnostic Technology Laboratory, Immunobiological Technology Institute (Bio-Manguinhos), Oswaldo Cruz Foundation (Fiocruz-RJ), Rio de Janeiro, Brazil.
Nilson Ivo Tonin ZanchinInterdisciplinary Research Group in Biotechnology and Epidemiology of Infectious Diseases (GRUPIBE), Gonçalo Moniz Institute, Oswaldo Cruz Foundation (FIOCRUZ-BA), Salvador, Brazil.
Fred Luciano Neves SantosAdvanced Public Health Laboratory, Gonçalo Moniz Institute, Oswaldo Cruz Foundation (Fiocruz-BA), Salvador, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Syphilis, a sexually transmitted infection caused by the bacterium

Indexed as

DAgS-ELISArecombinant proteinsyphilisTpN17treponemal test

Identifiers

PMID40270825
PMCPMC12014689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.