ArticleFrontiers in microbiology2025
Dietary fatty acids promote gut health in weaned piglets by regulating gut microbiota and immune function.
Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Artemisia argyi-enriched fermented soybean meal alleviates ETEC K88-induced intestinal injury in mice in association with gut microbiota remodeling and purine metabolic alterations.BMC veterinary research · 2026Article
- Short-, medium-, versus long-chain fatty acids: mechanisms of immunomodulation and disease pathogenesis.Cellular & molecular immunology · 2026Review
- Optimal ratio of laurate and butyrate from glyceride forms improves nutrient digestibility and health in weaned piglets.Animal bioscience · 2026Article
- Medium and short chain fatty acid monoglycerides as an antibiotic alternative reduce diarrhea, improve growth, and modulate gut microbiota in weaned piglets.Frontiers in veterinary science · 2026Article
- Stachyose attenuates DSS-induced colitis and is associated with elevated colonic medium-chain fatty acids: an integrated multi-omics analysis.NPJ science of food · 2025Article
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Authors and funding
10 authors.
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Abstract
Background: Post-weaning diarrhea in piglets is a common challenge that adversely impacts growth performance and increases mortality, leading to severe economic losses. Medium-chain fatty acids (MCFA) and short-chain fatty acids (SCFA) are frequently used as feed additives due to their bioactive properties. This study evaluated the effects of two different blends of MCFA and SCFA (VSM and VS + VM) as alternatives to zinc oxide (ZnO) on growth performance, nutrient digestibility, oxidative stress, inflammatory, and gut microbiota composition in weaned piglets. Methods and results: A total of 108 piglets (8.22 ± 0.51 kg) were randomly assigned to three treatments: control (CON, basal diet + ZnO), VSM (basal diet + higher MCFA and lower SCFA content) and VS + VM (basal diet + higher SCFA and lower MCFA content). Results indicated that Both VSM and VS + VM, can replace ZnO to relieve diarrhea of weaned piglets as evidenced by increased average daily gain (ADG) and decreased feed to gain ratio (F/G) in 1-15 days, with no difference in final body weight compared to the CON group. Additionally, dietary MCFA and SCFA supplementation improves anti-oxidative and anti-inflammatory capacity by decreased of malondialdehyde (MDA) activity, and inhibited proinflammatory cytokine tumor necrosis factor α (TNF-α) and interleukin (IL-1β, IL-17A) secretion. Further study showed that the protective effect of MCFA and SCFA were associated with restoring gut barrier, upregulating abundances of Interpretation: Collectively, the combination of MCFA and SCFA alleviated oxidative stress, modulated inflammation, and supported gut barrier function in weaned piglets, offering a promising alternative to ZnO, with VSM showing superior effects.
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