ArticleEClinicalMedicine2025
Qualitative and quantitative educational disparities and brain signatures in healthy aging and dementia across global settings.
Article in EClinicalMedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Trial
- Lesion-Level Subtypes of White Matter Hyperintensity Evolution Beyond Spatial Location.Neurology · 2026Observational
- The exposome of brain aging across 34 countries.Nature medicine · 2026Article
- The landscape of dementia research, diagnosis, treatment, and care in Latin America.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Blood-based AT(N) biomarkers for Alzheimer's disease and frontotemporal lobar degeneration in Latin America.Nature aging · 2026Article
- Advances in AI-based diagnosis of Alzheimer's disease using MRI: a comprehensive survey.Frontiers in medicine · 2026Review
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Dementia prevention requires moving beyond individual choice: the costs of effort and time intersect with social determinants of health.Neuroscience · 2025Review
- Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries.Nature aging · 2025Article
- Creative experiences and brain clocks.Nature communications · 2025Article
- Diversity-sensitive brain clocks linked to biophysical mechanisms in aging and dementia.Nature. Mental health · 2025Article
- The exposome of healthy and accelerated aging across 40 countries.Nature medicine · 2025Article
- Resilience and brain health in global populations.Nature medicine · 2025Review
- Biological imprint of education and rights-based brain capital.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Guaranteeing girls' right to education: an imperative for global brain health.Dementia & neuropsychologia · 2025Article
- County-level School Quality Education Measures During Ninth Grade and Brain Health Imaging Markers in Late Life.Alzheimer disease and associated disordersObservational
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Authors and funding
35 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: While education is crucial for brain health, evidence mainly relies on individual measures of years of education (YoE), neglecting education quality (EQ). The effect of YoE and EQ on aging and dementia has not been compared. Methods: We conducted a cross-sectional assessment of the effect of EQ and YoE on brain health in 7533 subjects from 20 countries, including healthy controls (HCs), Alzheimer's disease (AD), and frontotemporal lobar degeneration (FTLD). EQ was based on country-level quality indicators provided by the programme for international student assessment (PISA). After applying neuroimage harmonization, we examined its effect, along with YoE, on gray matter volume and functional connectivity. Regression models were adjusted for age, sex, and cognition, controlling for multiple comparisons. The influence of image quality was assessed through sensitivity analysis. Data collection was conducted between June 1 and October 30, 2024. Findings: Less EQ and YoE were associated with brain alterations across groups. However, EQ had a stronger influence, mainly targeting the critical areas of each condition. At the whole-brain level, EQ influenced volume (HCs: Δmean = 2·0 [1·9-2·0] × 10 Interpretation: The results support the need to incorporate education quality into studying and improving brain health, underscoring the importance of country-level measures. Funding: Multi-partner consortium to expand dementia research in Latin America (ReDLat).
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