Evidence map›Paper›PMID 40270710›Full record

ArticleComputational and structural biotechnology journal2025

A molecular dynamics study of membrane positioning for 7-transmembrane RGS proteins to modulate G-protein-mediated signaling in plants.

Celio Cabral Oliveira, Eduardo Bassi Simoni, Mariana Abrahão Bueno Morais, Elizabeth Pacheco Batista Fontes, Pedro A Braga Dos Reis, Daisuke Urano, Alan M Jones

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Computational and structural biotechnology journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. AlphaFold in protein structure and function prediction.Computational and structural biotechnology journal · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Celio Cabral OliveiraBrazilian Biorenewables National Laboratory (LNBR), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970, Brazil.
Eduardo Bassi SimoniDepartment of Biology, University of North Carolina, Chapel Hill, NC 27899, USA.
Mariana Abrahão Bueno MoraisBrazilian Biorenewables National Laboratory (LNBR), Brazilian Center for Research in Energy and Materials (CNPEM), Campinas, SP 13083-970, Brazil.
Elizabeth Pacheco Batista FontesDepartment of Biochemistry and Molecular Biology, BIOAGRO, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil.
Pedro A Braga Dos ReisDepartment of Biochemistry and Molecular Biology, BIOAGRO, Universidade Federal de Viçosa, Viçosa, MG 36570-000, Brazil.
Daisuke UranoTemasek Life Sciences Laboratory, 117604, Singapore.
Alan M JonesDepartment of Biology, University of North Carolina, Chapel Hill, NC 27899, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein phosphorylation regulates G protein signaling in plants. AtRGS1 primarily modulates AtGPA1, the canonical Gα subunit in the heterotrimeric G protein complex. AtRGS1 possesses both a seven-transmembrane (7TM) domain connected to a cytoplasmic Regulator of G Protein Signaling domain (RGS box domain) by a flexible linker region. This study presents the novel function of a highly conserved, known phosphorylation site, Ser278, within this linker region utilizing molecular dynamics (MD) simulations with

Indexed as

ArabidopsisHeterotrimeric G proteinLinker domainMolecular dynamicsProtein evolutionRegulator of G protein signaling (RGS)

Identifiers

PMID40270710
PMCPMC12017998

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.