Evidence map›Paper›PMID 40270581›Full record

ArticleMolecular imaging

Quantification of Multi-Organ 11β-Hydroxysteroid Dehydrogenase Type 1 Enzyme Levels in a Zucker Fatty Rat Model: A PET Imaging Study.

Jason Bini, Jordan Strober, Michael Kapinos, Ming-Qiang Zheng, Songye Li, Jim Ropchan, Nabeel Nabulsi, Yiyun Huang, Rachel J Perry, Daniel F Vatner and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jason BiniDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-4047-6575
Jordan StroberSection of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Michael KapinosDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Ming-Qiang ZhengDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Songye LiDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Jim RopchanDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Nabeel NabulsiDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Yiyun HuangDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.
Rachel J PerrySection of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
Daniel F VatnerSection of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID 0000-0003-2073-0273
Richard E CarsonDepartment of Radiology and Biomedical Imaging, Yale University School of Medicine, New Haven, CT, USA.

Funding

Metabolic heterogeneity underlying hypertriglyceridemia in insulin resistanceR01DK124272 · NIDDK · YALE UNIVERSITY · PI VATNER, DANIEL · 2020 to 2024
$2.3M
Direct measurement of 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) enzyme levels in obesity using a novel positron emissiontomography radioligandK01DK118005 · NIDDK · YALE UNIVERSITY · PI BINI, JASON · 2019 to 2023
$848k
Positron emission tomography to characterize beta cell mass in individuals from multiple stages in the progression of type 1 diabetesR03DK135445 · NIDDK · YALE UNIVERSITY · PI BINI, JASON · 2023 to 2023
$168k
NIDDK NIH HHS K01 DK118005NIDDK NIH HHS R01 DK124272NIDDK NIH HHS R03 DK135445
6 · The paper itself

Abstract

Background: In rodents, 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) catalyzes the conversion of inactive 11-dehydrocorticosterone to the active hormone corticosterone. Dysregulation of intracellular glucocorticoid action is implicated in metabolic diseases. Assessing 11β-HSD1 enzyme levels Objective: We used a Zucker Fatty (ZF) rat model and [ Material and Methods: To validate [ Results: Obesity is associated with decreased brain 11β-HSD1 levels, measured by [ Conclusion: We demonstrate that [

Indexed as

11-beta-Hydroxysteroid Dehydrogenase Type 1Positron-Emission TomographyAnimalsBrainDisease Models, AnimalKineticsLiverMaleObesityRatsRats, Zucker11-beta-Hydroxysteroid Dehydrogenase Type 111β-HSD1adipose tissuebraincorticosteronecortisolglucoseglycerolliverobesitypositron emission tomographyZucker fatty rat

Identifiers

PMID40270581
PMCPMC12014946

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.