ArticleJournal of inflammation research2025
Cervical Conization and Systemic Inflammatory Markers: The Predictive Value of Neutrophil Percentage to Albumin Ratio (NPAR) to Identify High-Grade Cervical Intraepithelial Neoplasia (CIN).
Article in Journal of inflammation research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Development and validation of a neutrophil percentage to albumin ratio-based nomogram for predicting survival in patients with locally advanced gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2026Article
- Association between neutrophil percentage-to-albumin ratio and all-cause mortality in patients post-cardiac surgery: a retrospective cohort study.Molecular and cellular biochemistry · 2026Article
- Establishment and evaluation of a novel tool based on inflammation-nutrition derived biomarkers for early diagnosis of diabetic foot ulcers.Frontiers in immunology · 2026Article
- Systemic Inflammatory Indices-Systemic Immune-Inflammation Index (SII) and the Systemic Inflammation Response Index (SIRI)-As Potential Rule-Out Biomarkers for Invasive Cervical Carcinoma.International journal of molecular sciences · 2025Observational
- The prognostic value of preoperative Neutrophil-to-Albumin ratio (NPAR) for postoperative complications and survival in colorectal cancer patients undergoing robot-assisted surgery: a retrospective cohort study.Journal of robotic surgery · 2025Article
- The prognostic role of inflammation-based hematologic markers in stage I-III colorectal cancer: a retrospective analysis.BMC cancer · 2025Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to evaluate the predictive value of systemic inflammatory markers, particularly the Neutrophil Percentage to Albumin Ratio (NPAR), in identifying high-grade cervical intraepithelial neoplasia (CIN) in patients undergoing colposcopy and cervical conization. Materials and Methods: A retrospective analysis was conducted on 116 patients who underwent cervical conization between January 2020 and May 2024. Demographic, clinical, and laboratory data were collected, and inflammatory indices, including NPAR, NLR (Neutrophil-to-Lymphocyte Ratio), PLR (Platelet-to-Lymphocyte Ratio), and SII (Systemic Immune-Inflammation Index), were calculated. Sample size estimation was based on prior studies assessing inflammatory markers in CIN, ensuring adequate statistical power for detecting differences in biomarker levels. ROC curve analysis was performed to assess the diagnostic accuracy of these markers. Results: NPAR demonstrated the highest predictive value for high-grade CIN, with an AUC of 0.893. Significant correlations were found between NPAR and other systemic inflammatory markers, such as NLR and SII. However, NLR and PLR showed lower predictive accuracy compared to NPAR. Conclusion: NPAR is a valuable biomarker for predicting high-grade CIN and can aid in patient stratification and treatment planning. Integrating NPAR with other systemic markers may enhance the accuracy of clinical decisions. Further studies with larger cohorts are recommended to validate these findings and explore their clinical utility.
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