ArticleFrontiers in genetics2025
Identification of signature genes and relationship with immune cell infiltration in intervertebral disc degeneration.
Article in Frontiers in genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Screening and identification of differentially expressed miRNA and mRNA for intervertebral disc degeneration on bioinformatics.European journal of medical research · 2025Article
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4 authors.
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Abstract
Background: Early diagnosis of intervertebral disc (IVD) degeneration is of great significance for prevention of the disease from progressing to a serious stage. This study aimed to investigate the signature genes and their association with immune cells in IVD degeneration. Methods: We analyzed differentially expressed genes (DEGs) in a dataset of IVD degeneration samples from the GEO database. Weighted gene coexpression network analysis (WGCNA) and DEGs were employed to pinpoint the key modules and IVD degeneration genes. Functional enrichment analysis was performed for these IVD degeneration genes. Signature genes were identified using least absolute shrinkage and selection operator (LASSO) analysis. Gene set enrichment analysis (GSEA) was used to explore signaling pathways related to signature genes, and CIBERSORT Results: 2,254 DEGs were identified from GSE56081, and WGCNA grouped the data into 9 modules. MEbrown module had a significant correlation with IVD degeneration (cor = 0.99, Conclusion: TOB1 may show remarkable diagnostic performance in IVD degeneration and may be implicated in the infiltration of immune cells.
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