Evidence map›Paper›PMID 40270528›Full record

ArticleEnvironment & health (Washington, D.C.)2025

Associations between Per- and Polyfluoroalkyl Substances Exposures and Bone Mineral: A Systematic Review and Best Evidence Synthesis.

Kai Tao, Bin Zeng, Linghui Deng, Wei Zhang, Xianghong Zhou, Yuming Jin, Zilong Zhang, Weichao Huang, Xiaoli Zou, Yu Zhan and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Kai TaoDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.ORCID https://orcid.org/0009-0005-7957-5281
Bin ZengDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Linghui DengNational Clinical Research Center of Geriatrics, The Center of Gerontology and Geriatrics, West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.
Wei ZhangDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Xianghong ZhouDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Yuming JinDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Zilong ZhangDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Weichao HuangDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Xiaoli ZouDepartment of Sanitary Technology, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, Sichuan Province 610041, China.ORCID https://orcid.org/0000-0002-9657-189X
Yu ZhanDepartment of Environmental Science and Engineering, Sichuan University, Chengdu, Sichuan Province 610065, China.ORCID https://orcid.org/0000-0002-8473-2799
Ping LuPathology Department, No. 3 Affiliated Hospital of Chengdu University of Traditional Chinese Medicine (West District), Chengdu, Sichuan Province 611137, China.
Shi QiuDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Lu YangDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.
Qiang WeiDepartment of Urology, Institute of Urology and National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu, Sichuan Province 610041, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their bioaccumulative nature. Reduced bone mineral density (BMD) is associated with an increased risk of developing osteoporosis. This pioneering study aims to assess the effects of different PFAS compounds on bone mineral. We conducted searches on online databases. Inclusion criteria included the presence of associations between perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonic acid (PFHxS), perfluorononanoic acid (PFNA), and perfluorodecanoic acid (PFDA) and BMD, BMD z-score, and bone mineral content (BMC). Meta-analyses were performed. Best evidence synthesis (BES) was performed to summarize the results. The results of BES showed that the evidence of PFOS, PFOA and PFNA with reduced bone mineral were moderate. The variability in methods for assessing bone mineral and sex differences are potential sources of heterogeneity in the results. Meta analysis showed that PFOA was associated with BMD (β -0.01, 95% CI -0.01 to -0.00;

Identifiers

PMID40270528
PMCPMC12012664

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.