Evidence map›Paper›PMID 40270458›Full record

ArticleArtificial organs2025

In Vitro Comparison of Device-Induced Hemolysis, Platelet Defects, and von Willebrand Factor Degradation Between the HeartMate 2 and HeartMate 3 Pumps.

John Vandenberge, Dong Han, Wenji Sun, Shigang Wang, Douglas Tran, Nancy Kim, Kiersten Clark, Randy Perez, Bartley P Griffith, Zhongjun J Wu

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Artificial organs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

John VandenbergeArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Dong HanArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Wenji SunArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Shigang WangArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Douglas TranArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Nancy KimArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Kiersten ClarkArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Randy PerezArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Bartley P GriffithArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.
Zhongjun J WuArtificial Organs Lab, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0003-0807-7195

Funding

First-in-Human Use of an Artificial Lung for Ambulatory Respiratory SupportR01HL118372 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI GRIFFITH, BARTLEY P, WU, ZHONGJUN JON · 2013 to 2023
$7.9M
Computational Modeling of Device-Induced Platelet Activation and Receptor Shedding Relevant to Thrombosis and Bleeding in Device-Assisted CirculationR01HL162940 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Zhongjun Jon Wu · 2023 to 2026
$2.0M
High Mechanical Shear Stress-Induced Neutrophil Dysfunction in Mechanically Assisted CirculationR01HL171120 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Zhongjun Jon Wu · 2024 to 2026
$1.8M
NHLBI NIH HHS R01 HL118372NHLBI NIH HHS R01 HL162940NHLBI NIH HHS R01 HL171120NIH HHS
6 · The paper itself

Abstract

backgroundLeft ventricular assist devices (LVADs) have been utilized to maintain the circulatory demands of patients with end-stage heart failure. Despite their positive impact, hemocompatibility-related adverse events remain a major challenge. The aim of this study is to compare in vitro hemocompatibility performance between the HeartMate 2 (HM2) and HeartMate 3 (HM3) pumps by assessing device-induced blood damage in an in vitro circulatory loop.

methodsFresh healthy human blood was circulated for 4 h in a circulatory loop assisted by an HM2 or HM3 pump at a flow rate of 4.5 L/min and a pressure head of 75 mmHg. Hourly blood samples were collected for analysis of hemolysis, platelet activation, platelet receptor shedding, and high molecular weight multimer (HMWM) degradation of von Willebrand factor (VWF).

resultsThe data from the hourly blood samples showed that the HM3 pump caused significantly lower levels of hemolysis, platelet activation, platelet receptor shedding, and HMWM degradation of VWF compared to the HM2 pump.

conclusionThe HM3 exhibited superior overall hemocompatibility to the HM2, underscoring the advantages of the fully magnetically levitated centrifugal pump design in the HM3 compared to the mechanical bearing-supported axial pump design of the HM2.

Indexed as

Blood PlateletsHeart-Assist DevicesHemolysisvon Willebrand FactorHumansMaterials TestingPlatelet ActivationProsthesis Designvon Willebrand Factorblood damageheart failureHeartMate 2HeartMate 3hemolysisplatelet activationventricular assist device

Identifiers

PMID40270458
PMCPMC12353324

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.