Evidence map›Paper›PMID 40270298›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2025

Bioactive Glass Microscaffolds Fabricated by Two-Photon Lithography.

Leonhard Hambitzer, Jan Mathis Hornbostel, Louise Roolfs, Richard Prediger, Sebastian Kluck, Kai Zheng, Cornelia Lee-Thedieck, Frederik Kotz-Helmer

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Enzyme-Integrated Hydrogels for Advanced Biological Applications.Polymer science & technology (Washington, D.C.) · 2026
    Review
  6. Bioactive Glass Microscaffolds Fabricated by Two-Photon Lithography.Advanced materials (Deerfield Beach, Fla.) · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Leonhard HambitzerLaboratory of Process Technology, NeptunLab, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Köhler-Allee 103, 79110, Freiburg, Germany.ORCID https://orcid.org/0000-0001-7032-9918
Jan Mathis HornbostelInstitute of Cell Biology and Biophysics, Department of Cell Biology, University of Hannover, Herrenhäuser Straße 2, 30419, Hannover, Germany.ORCID https://orcid.org/0009-0006-0282-5673
Louise RoolfsInstitute of Cell Biology and Biophysics, Department of Cell Biology, University of Hannover, Herrenhäuser Straße 2, 30419, Hannover, Germany.
Richard PredigerLaboratory of Process Technology, NeptunLab, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Köhler-Allee 103, 79110, Freiburg, Germany.
Sebastian KluckLaboratory of Process Technology, NeptunLab, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Köhler-Allee 103, 79110, Freiburg, Germany.
Kai ZhengEngineering Research Center of Stomatological Translational Medicine & Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Nanjing, 210029, China.
Cornelia Lee-ThedieckInstitute of Cell Biology and Biophysics, Department of Cell Biology, University of Hannover, Herrenhäuser Straße 2, 30419, Hannover, Germany.ORCID https://orcid.org/0000-0001-8863-5403
Frederik Kotz-HelmerLaboratory of Process Technology, NeptunLab, Department of Microsystems Engineering (IMTEK), University of Freiburg, Georges-Köhler-Allee 103, 79110, Freiburg, Germany.ORCID https://orcid.org/0000-0001-8376-154X

Funding

Baden-Württemberg StiftungDeutsche Forschungsgemeinschaft KO 6240/2-1
6 · The paper itself

Abstract

Porous scaffolds made of bioactive glass (BG) are of great interest for tissue engineering as they can bond to bone rapidly and promote new bone formation. Pores and channels between 100 and 500 µm provide space for cell intrusion and nutrient supply, facilitating bone ingrowth and vascularization. Furthermore, smaller pores and structural features of a few microns in size influence cell behavior, such as adhesion and osteogenic differentiation. Additive manufacturing (AM) is well suited to fabricate such geometries. However, microstructuring BG is demanding and common AM techniques are unable to achieve features below 100 µm. In this work, two-photon lithography (TPL) is used for the first time to structure BG with single-micron features. A composite containing BG nanoparticles is structured using TPL and thermally processed to receive glass scaffolds. The glass used in this study demonstrates in vitro bioactivity in simulated body fluid (SBF) and cytocompatibility toward human mesenchymal stromal cells (MSCs), making it a suitable material for tissue engineering. This process will open a toolbox for a variety of existing BG particles to be shaped with features as small as 6 µm and will broaden the understanding of the influence of scaffold design on cell behavior.

Indexed as

Biocompatible MaterialsGlassPhotonsTissue ScaffoldsHumansMesenchymal Stem CellsNanoparticlesPorosityTissue EngineeringBiocompatible Materialsbioactive glassmicroscaffoldnanoparticlestissue engineeringtwo‐photon lithography

Identifiers

PMID40270298
PMCPMC12288830

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.