Evidence map›Paper›PMID 40270278›Full record

ArticleBiomarkers in medicine2025

Association of APOB (rs515135) and PCSK9 (rs505151) gene polymorphisms with CAD in the Indian population.

Ale Eba, Syed Tasleem Raza, Irshad Ahmad Wani, Bashir Ahmad, Mohammad Abbas, Zeba Siddiqi, Sanchita Srivastava, Farzana Mahdi

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Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ale EbaDepartment of Biotechnology, Era's Lucknow Medical College and Hospital, Lucknow, India.
Syed Tasleem RazaDepartment of Biochemistry, Era's Lucknow Medical College and Hospital, ERA University, Lucknow, India.
Irshad Ahmad WaniDepartment of Medicine (Cardiology Unit), Eras Lucknow Medical College and Hospital, Era University, Lucknow, India.
Bashir AhmadDepartment of Medicine (Cardiology Unit), Eras Lucknow Medical College and Hospital, Era University, Lucknow, India.
Mohammad AbbasDepartment of Personalized and Molecular Medicine, Era University, Lucknow, India.
Zeba SiddiqiDepartment of Medicine, Era's Lucknow Medical College and Hospital, Lucknow, India.
Sanchita SrivastavaDepartment of Biotechnology, Era's Lucknow Medical College and Hospital, Lucknow, India.
Farzana MahdiDepartment of Personalized and Molecular Medicine, Era University, Lucknow, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCoronary artery disease (CAD) is a multifactorial disorder influenced by both genetic and clinical risk factors. Lipid metabolism genes such as apolipoprotein B(APOB) (rs515135) and proprotein convertase subtilisin/kexin type 9 (PCSK9)(rs505151), have been associated with susceptibility to CAD. Study investigates the potential role of these genetic polymorphisms with risk of CAD in the Indian population. MATERIALS AND

methodsA case-control study including 150 CAD cases and 150 controls. Angiographically proven Cases were recruited from the Cardiology Unit, Department of Medicine, Era's Lucknow Medical College. Genotyping was done using specific primers and restriction digestion; statistical analysis included t-tests, odds ratios, and haplotype analysis.

resultsCAD cases(mean age 49.93   ±   9.13 years) had higher serum cholesterol and VLDL but lower systolic and diastolic BP compared to controls (mean age 56.47   ±   9.39 years). The APOB G allele showed a significant protective effect against CAD (OR: 0.431,

conclusionThe APOB G allele may serve as a protective factor against CAD, highlighting its potential role in genetic screening for lower disease risk. Further large-scale studies are required to confirm these findings.

Indexed as

Apolipoprotein B-100Apolipoproteins BCoronary Artery DiseasePolymorphism, Single NucleotideProprotein Convertase 9AdultAgedAllelesCase-Control StudiesFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansIndiaAPOB protein, humanApolipoprotein B-100Apolipoproteins BPCSK9 protein, humanProprotein Convertase 9APOB (rs515135)cardiovascular diseasecoronary artery diseasegene polymorphismIndian populationlipid metabolismodds ratioPCSK9 (rs505151)

Identifiers

PMID40270278
PMCPMC12077466

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