ArticleAdvanced healthcare materials2025
Extracellular Matrix-Mediated Crosslinking of Adhesive Hyaluronic Acid Patch for Treating Volumetric Muscle Injury.
Article in Advanced healthcare materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Developing Metal-Polyphenol Network-Based Single-Protein Particle Encapsulation System for Sustained Release of Whey Protein to Mitigate Sarcopenia.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hydrogels for Skeletal Muscle Regeneration: Design, Fabrication, and Future Applications.ACS polymers Au · 2026Review
- Mechanically Spatio-Chimeric Fibrin Assembly Enables Vascular-Integrated Muscle Reconstruction for Volumetric Muscle Loss Repair.Advanced materials (Deerfield Beach, Fla.) · 2026Article
- Extracellular Matrix-Mediated Crosslinking of Adhesive Hyaluronic Acid Patch for Treating Volumetric Muscle Injury.Advanced healthcare materials · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
The treatment of volumetric muscle loss (VML) is challenging owing to the deficiency of appropriate bioscaffolds and ineffective therapeutic outcomes with conventional approaches. Adhesive hydrogels have emerged as potential tools for promoting tissue regeneration, offering effective integration with damaged tissues. However, technical procedures requiring non-biocompatible crosslinking methods, mechanical mismatches, or the absence of tissue-specific microenvironments in conventional adhesive hydrogels have hindered their successful application in tissue reconstruction. In this study, a patch-type adhesive hydrogel is developed by combining a muscle tissue-derived extracellular matrix (MEM) and catechol-conjugated hyaluronic acid (HA-CA). This MEM-containing HA-CA (HCM) patch hydrogel utilizes MEM as both a biocompatible crosslinker and a therapeutic substance. The HCM patch hydrogel, crosslinked through a combination of covalent and non-covalent interactions via MEM and catechol in the composite, not only provides stable physical support but also develops muscle tissue-specific biochemical cues, mediating the recruitment and maturation of muscular cells. In animal models of VML, the HCM patch hydrogel effectively stimulates satellite cells and supports de novo muscle regeneration with functional restoration. This study emphasizes the efficacy and ready-to-use convenience of HCM patch hydrogels for muscle regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.