ArticleMedical physics2025
Optimization of microwave hyperthermia system for focused breast cancer treatment: A study using realistic digital breast phantoms.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Microwave technologies for biomedical diagnosis and therapy: advances, challenges, and perspectives.Mikrochimica acta · 2026Review
- A stacked cavity-backed metamaterial antenna for confined hyperthermia of subcutaneous fat in ISM band.Frontiers in medical technology · 2026Article
- Optimization of microwave hyperthermia system for focused breast cancer treatment: A study using realistic digital breast phantoms.Medical physics · 2025Article
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3 authors.
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Abstract
backgroundMicrowave breast hyperthermia is a noninvasive treatment method for breast cancer that utilizes microwave energy (ME) sources to raise tissue temperatures above 42 PURPOSE: In this work, we propose an approach to optimize the microwave hyperthermia system, employing phase and amplitude modulation techniques to concentrate the electric field at the center of a malignant tumor within a breast medium. The approach uses line sources arranged in a circular pattern around realistic breast models. The method begins by determining the phase, followed by adjusting the amplitudes of each source in order to maximize the total electric field at the tumor's center. The goal is to maximize the electric field at the tumor center while minimizing the optimization cost and complexity.
methodsSimulations are performed at 4 GHz frequency using two different types of digital breast phantoms (fatty and dense breasts) as test beds. The algorithm is tested by using three quantities; that is, the electric field distribution, the power density distribution, and the temperature distribution inside the whole breast region. The electric field and power density are calculated using an in-house method of moments (MoM) algorithm, while the temperature distributions are obtained with computer simulation technology (CST) software. To further evaluate the method with quantitative measures of success, thermal indices are calculated for each phantom and method.
resultsThe specific absorbtion rate (SAR) results and corresponding temperature distributions for each breast type and optimization demonstrate that effective focusing is achieved in both cases. However, the combined phase-amplitude optimization provides more precise focusing by eliminating hot spots. Among thermal indices, the TC75 and T90 values obtained from the phase-amplitude combined optimization for both breast types outperform the results found in the literature. The T50 values obtained using the combined optimization are above 42
conclusionsThis study presents an optimization method for focusing ME within breast tissue, performed in two steps: first phase optimization, followed by amplitude optimization. The electric field calculations are performed using both the MoM and Finite Difference Time Domain methods. The technique is numerically tested on two realistic breast models, with thermal indices calculated for each phantom and optimization process. Results show T90 values exceeding 40
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