ArticleCardio-oncology (London, England)2025
Coronary artery calcification score as a prognostic factor in younger patients with multiple myeloma undergoing autologous stem cell therapy.
Article in Cardio-oncology (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Coronary artery calcification score as a prognostic factor in patients undergoing allogeneic stem cell transplantation - a retrospective analysis.Cardio-oncology (London, England) · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCoronary artery calcification (CAC) scoring can be performed as a by-product of computed tomography (CT). CAC scoring may reflect the general cardiovascular risk profile of patients. The aim of the present study was to determine the impact of CAC on overall survival (OS) in patients with multiple myeloma (MM).
methodsA retrospective analysis was conducted on all patients with MM undergoing peripheral blood stem cell transplantation between the years 2009 and 2019. A total of 127 patients (50 female patients, 39.4%) with a mean age of 57.8 ± 7.6 years were included in the analysis. A whole-body CT scan was used to assess the CAC score for each patient. The Weston score as a surrogate for Agatston score was applied in the non-gated staging CT images.c
resultsA total of 27 patients (22.0%) died during the course of the study. The CAC score did not differ between non-survivors and survivors in the discrimination analysis (mean 1.2 ± 2.4 versus 2.0 ± 2.8, p = 0.13). The CAC score showed no correlation with overall survival, with an HR of 0.92 (95% CI 0.78-1.09, p = 0.35). Of the patients without calcification (CAC score 0, n = 66, 51.9%), 18 died, while of those with calcification (CAC score 1 or higher, n = 61, 48.1%), nine died. The results of the Fisher's exact test showed no statistically significant difference between the two groups (p = 0.20).
conclusionsThe presence of CT-defined coronary calcifications does not predict survival in younger patients with multiple myeloma undergoing autologous stem cell therapy and comparably short survival. The impact of CT-defined cardiovascular risk factors appears to be relatively modest in this heterogeneous disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.