Evidence map›Paper›PMID 40270067›Full record

ArticleEuropean journal of medical research2025

Late neurological improvement during hospitalization is a predicative factor for acute ischemic stroke.

Huimin Zhao, Qinrong Xu, Peng Chen, Xiaojing Guo, Guanhui Wu

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Article in European journal of medical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed
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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Huimin Zhao *Department of Neurology, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215000, Jiangsu, People's Republic of China.
Qinrong Xu *Department of Neurology, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215000, Jiangsu, People's Republic of China.
Peng ChenDepartment of Psychiatry, Suzhou Psychiatric Hospital, Institute of Mental Health, the Affiliated Guangji Hospital of Soochow University, Suzhou, 215137, Jiangsu, People's Republic of China.
Xiaojing GuoDepartment of Neurology, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215000, Jiangsu, People's Republic of China. guoxj@njmu.edu.cn.
Guanhui WuDepartment of Neurology, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, 215000, Jiangsu, People's Republic of China. ghwusz26@njmu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis study aimed to investigate whether late neurological improvement (LNI) during hospitalization serves as a favorable prognostic indicator in patients with acute ischemic stroke (AIS) and to identify the predictors of LNI.

methodsWe retrospectively analyzed data from the Safe Implementation of Treatments in Stroke (SITS) registry at two stroke centers in Egypt. LNI was defined as the lack of early neurological improvement (ENI) within 24 h after admission, accompanied by neurological improvement within 7 days of hospitalization. Multivariate logistic regression was employed to analyze the factors influencing favorable prognosis (modified Rankin Scale score 0-2) and LNI.

resultsA total of 834 patients with AIS were included in this study, of which 130 (15.6%) exhibited LNI. Among these, 99 (76.2%) achieved favorable outcomes. Both ENI (OR = 6.756, 95% CI 3.355-13.603, P < 0.001) and LNI (OR = 5.760, 95% CI 3.146-10.545, P < 0.001) were independently associated with favorable prognosis after adjustment. Predictors of LNI in multivariable-adjusted logistic regression included younger age (OR = 0.973, 95% CI 0.957-0.990, P = 0.001), higher baseline National Institutes of Health Scale (NIHSS) score (OR = 1.196, 95% CI 1.146-1.248, P < 0.001), and rt-PA treatment (OR = 1.953, 95% CI 1.206-3.163, P = 0.006).

conclusionsApproximately three-quarters of patients with LNI are expected to achieve good outcome. LNI was a favorable prognostic indicator in patients with AIS and younger age, higher baseline NIHSS score and rt-PA treatment predicted LNI.

Indexed as

HospitalizationIschemic StrokeAgedEgyptFemaleHumansMaleMiddle AgedPrognosisRegistriesRetrospective StudiesAcute ischemic strokeEarly neurological improvementLate neurological improvementPrognosis

Identifiers

PMID40270067
PMCPMC12020043

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