ArticleMedical physics2025
Medical physics dataset article: A database of FLASH murine in vivo studies.
Article in Medical physics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Systematic analysis of biological endpoint variability and implications for quantitative modeling of the FLASH sparing effect.Physics and imaging in radiation oncology · 2026Review
- First-in-human e-Flash radiotherapy using a modified conventional C-arm linear accelerator.Clinical and translational radiation oncology · 2026Article
- The potential and risks of FLASH radiotherapy in pediatric patients.Neuro-oncology pediatrics · 2026Review
- Quality assurance and reporting for FLASH clinical trials: The experience of the FEATHER trial.Medical physics · 2025Article
- Medical physics dataset article: A database of FLASH murine in vivo studies.Medical physics · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeThe FLASH effect refers to a lower normal tissue damage for an equivalent tumor response, potentially widening the therapeutic window for radiotherapy. Although this effect has been demonstrated in various experiments using different types of particles and irradiation parameters, the underlying mechanism is not yet clearly understood. Uncertainties surround the conducted experiments, the explored parameter space, and the variability of reported results. To gain a better overview, we have created a dataset that includes in vivo FLASH experiments. This dataset documents all machine and biological dosimetric parameters, and for determined endpoints, it includes the outcome of the experiment. Our goal with this database is to increase awareness of the results and their variability and provide a useful research and analysis tool for the community. ACQUISITION AND VALIDATION
methodsThe database contains peer-reviewed papers published until March 2024 on the FLASH in vivo (murine) experiments. From each paper, previously defined parameters have been manually extracted and/or recalculated to ensure compatibility within the database entries. DATA FORMAT AND USAGE NOTES: We provide two types of datasets: a user-friendly web-based Notion database and spreadsheets on a Zenodo repository. The database contains all the reviewed papers with extracted information in text or numeric form. Users can duplicate the database or view, search, filter, and reorganize online entries. The spreadsheets contain the data for the most analyzed endpoints (skin toxicity, survival rate, and crypt cells), allowing a comparative analysis. POTENTIAL APPLICATIONS: The study has two main applications. The web-based database will allow for a user-friendly search of information and metadata of all published FLASH murine data. This will facilitate future research efforts to better understand the FLASH effect. The spreadsheets are a simple and useful tool for the community to conduct statistical analysis and determine the parameters associated with the FLASH effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.