Evidence map›Paper›PMID 40270056›Full record

ArticleCancer imaging : the official publication of the International Cancer Imaging Society2025

Evaluation of 3D ARFI imaging of prostate cancer: diagnostic reliability and concordance with MpMRI.

Spencer R Moavenzadeh, Derek Y Chan, Eric S Adams, Sriram Deivasigamani, Srinath Kotamarti, Mark L Palmeri, Thomas J Polascik, Kathryn R Nightingale

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer imaging : the official publication of the International Cancer Imaging Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04607135 (Acoustic Radiation Force Impulse), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04607135 naterminatednot on this map

Acoustic Radiation Force Impulse (ARFI) Imaging for Targeted Prostate Biopsy

TypeinterventionalSponsorDuke UniversityRan2021 to 2023Enrolled34ConditionsProstate CancerArmsAcoustic radiation force impulse (ARFI), Ultrasound
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Spencer R MoavenzadehDepartment of Biomedical Engineering, Duke University, Room 1427, FCIEMAS, 101 Science Drive, Box 90281, Durham, NC, 27708, USA. spencer.moavenzadeh@duke.edu.
Derek Y ChanDepartment of Biomedical Engineering, Duke University, Room 1427, FCIEMAS, 101 Science Drive, Box 90281, Durham, NC, 27708, USA.
Eric S AdamsDepartment of Urology, Duke University Medical Center, Durham, NC, USA.
Sriram DeivasigamaniDepartment of Urology, Duke University Medical Center, Durham, NC, USA.
Srinath KotamartiDepartment of Urology, Duke University Medical Center, Durham, NC, USA.
Mark L PalmeriDepartment of Biomedical Engineering, Duke University, Room 1427, FCIEMAS, 101 Science Drive, Box 90281, Durham, NC, 27708, USA.
Thomas J PolascikDepartment of Urology, Duke University Medical Center, Durham, NC, USA.
Kathryn R NightingaleDepartment of Biomedical Engineering, Duke University, Room 1427, FCIEMAS, 101 Science Drive, Box 90281, Durham, NC, 27708, USA.

Funding

Radiation Force Imaging of Prostate Cancer and Guidance of Biopsy ProceduresR01CA142824 · NCI · DUKE UNIVERSITY · PI NIGHTINGALE, KATHRYN RADABAUGH · 2010 to 2021
$4.4M
NCI NIH HHS R01 CA142824NIH HHS R01-CA142824
6 · The paper itself

Abstract

purposeThe prevalence of prostate cancer (PCa) necessitates advanced diagnostic approaches for detection and lesion characterization. Utilizing two patient cohorts (n = 85), this study analyzes a custom-designed 3D ultrasonic acoustic radiation force impulse (ARFI) elasticity imaging system alongside an Index of Suspicion (IOS) lesion ranking system to evaluate reader sensitivity, positive predictive values, inter-reader reliability, and ARFI-mpMRI concordance. The IOS system provides standardized criteria for lesion assessment, enabling consistency in stratifying PCa lesion suspicion. MATERIALS AND

methodsThree readers were trained on multiparametric ultrasound (mpUS) (combined ARFI and B-mode) prostate image volumes from 6 patients based on the IOS criteria. The readers then marked suspicious lesions in 79 patients who were retrospectively compared with histopathology-identified (Cohort I, post-radical prostatectomy) or biopsy-confirmed (Cohort II) cancerous regions.

resultsThe IOS criteria stratified lesions by Gleason grade (GG), with a higher IOS correlating with more aggressive lesions. mpUS imaging was more sensitive for detecting lesions with higher GG and preferentially identified lesions with lower MR apparent-diffusion coefficients and signs of extraprostatic extension. mpUS imaging demonstrated substantial inter-reader reliability and moderate overlap with mpMRI lesions, with increasing sensitivity to higher MRI PI-RADS score lesions. mpUS imaging was less sensitive than mpMRI to lesions with lower GG.

conclusionsThe increased sensitivity of mpUS imaging to higher GG lesions and adverse histopathological factors, along with moderate agreement with mpMRI, suggest that mpUS has the potential to guide biopsy targeting of mpMRI-visible lesions or serve as an alternative biopsy-targeting approach when mpMRI is unavailable or clinically contraindicated.

Indexed as

Elasticity Imaging TechniquesImaging, Three-DimensionalMultiparametric Magnetic Resonance ImagingProstatic NeoplasmsAgedHumansMaleMiddle AgedNeoplasm GradingReproducibility of ResultsRetrospective StudiesAcoustic radiation force impulse imagingElasticity imagingNeedle biopsyProstate cancerUltrasound

Identifiers

PMID40270056
PMCPMC12020010

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Registered trials

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