Evidence map›Paper›PMID 40270049›Full record

ArticleBiological research2025

Chaperone-assisted E3 ligase-engineered mesenchymal stem cells target hyperglycemia-induced p53 for ubiquitination and proteasomal degradation ameliorates self-renewal.

Ayaz Ali, Wei-Wen Kuo, Chia-Hua Kuo, Jeng-Feng Lo, Dennis Jine-Yuan Hsieh, Peiying Pai, Tsung-Jung Ho, Marthandam Asokan Shibu, Shinn-Zong Lin, Chih-Yang Huang

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Article in Biological research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Ayaz AliAberdeen Cardiovascular and Diabetes Centre, Institute of Medical Sciences, University of Aberdeen, Aberdeen, UK.
Wei-Wen KuoDepartment of Biological Science and Technology, China Medical University, Taichung, 404, Taiwan.
Chia-Hua KuoLaboratory of Exercise Biochemistry, University of Taipei, Taipei, Taiwan.
Jeng-Feng LoInstitute of Oral Biology, National Yang-Ming University, Taipei, Taiwan.
Dennis Jine-Yuan HsiehSchool of Medical Technology, Chung Shan Medical University, Taichung, Taiwan.
Peiying PaiSchool of Medicine, College of Medicine, China Medical University, Taichung, 40402, Taiwan.
Tsung-Jung HoDepartment of Chinese Medicine, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Tzu Chi University, Hualien, Taiwan.
Marthandam Asokan Shibu *Department of Biotechnology, Bharathiar University, Coimbatore, India.
Shinn-Zong Lin *Bioinnovation Center, Buddhist Tzu Chi Medical Foundation, Hualien, 970, Taiwan.
Chih-Yang Huang *Graduate Institute of Biomedical Sciences, China Medical University, Taichung, 404, Taiwan. cyhuang@mail.cmu.edu.tw.ORCID http://orcid.org/0000-0003-2347-0411

Funding

China Medical University and Asia University, Taiwan CMU 107-ASIA-01Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation IMAR 110-01-11, TCRD 110-77
6 · The paper itself

Abstract

backgroundStem cell therapies may potentially be used in regenerative and reconstructive medicine due to their ability for self-renewal and differentiation. Stressful conditions, such as hyperglycemia, adversely affect stem cell functions, impairing their function and promoting differentiation by opposing self-renewal. The carboxyl terminus of HSP70 interacting protein (CHIP), which is a cochaperone and E3 ligase, maintains protein homeostasis and performs quality control of the cell via ubiquitylation. However, the role of CHIP in regulating stemness remains unknown.

resultsHyperglycemia downregulated CHIP-induced p53, arrested the cell cycle at the gap (G

conclusionsCHIP may promote ubiquitin-mediated proteasomal degradation of hyperglycemia-induced p53 rescues self-renewal genes, which can maintain the long-term undifferentiated state of WJMSCs. CHIP may be an alternative therapeutic option in regenerative medicine for hyperglycemic-related complications in diabetes.

Indexed as

Cell Self RenewalHyperglycemiaMesenchymal Stem CellsProteasome Endopeptidase ComplexTumor Suppressor Protein p53UbiquitinationUbiquitin-Protein LigasesAnimalsBlotting, WesternCell DifferentiationMolecular ChaperonesReal-Time Polymerase Chain ReactionMolecular ChaperonesProteasome Endopeptidase ComplexTumor Suppressor Protein p53Ubiquitin-Protein LigasesCarboxyl terminus of HSP70 interacting proteinHyperglycemiaMesenchymal stem cellsp53Self-renewal

Identifiers

PMID40270049
PMCPMC12020092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.