Evidence map›Paper›PMID 40270036›Full record

Trial reportCritical care (London, England)2025

Health-related quality of life correlates with patient-reported and proxy-reported disability in critical illness survivors: a secondary analysis of the ERIC trial.

Elena Ribet Buse, Julius J Grunow, Claudia D Spies, Björn Weiss, Nicolas Paul

Registry-linked trialAbstract readRandomized Controlled TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Critical care (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03671447 (Enhanced Recovery After Intensive Care), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03671447 nacompletednot on this map

Enhanced Recovery After Intensive Care (ERIC) - a Multi-Center Stepped Wedge Cluster-Randomized Controlled Trial

TypeinterventionalSponsorCharite University, Berlin, GermanyRan2018 to 2020Enrolled1,463ConditionsCritical IllnessArmsICU Usual Care, Tele-ICU
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Observational
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Elena Ribet BuseDepartment of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.ORCID http://orcid.org/0000-0001-6816-0623
Julius J GrunowDepartment of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.ORCID http://orcid.org/0000-0003-4164-0138
Claudia D SpiesDepartment of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.ORCID http://orcid.org/0000-0002-1062-0495
Björn WeissDepartment of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.ORCID http://orcid.org/0000-0003-3139-595X
Nicolas PaulDepartment of Anesthesiology and Intensive Care Medicine (CCM/CVK), Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Augustenburger Platz 1, 13353, Berlin, Germany. nicolas.paul@charite.de.ORCID http://orcid.org/0000-0003-2228-3980

Funding

German Innovation Fund (Innovationsfonds) 01NVF16011
6 · The paper itself

Abstract

backgroundExpanding follow-up services for survivors of critical illness requires short and reliable instrument sets. The WHO Disability Assessment Schedule (WHODAS) 2.0 and the EuroQol 5-Dimensions 5-Level (EQ-5D-5L) are recommended to assess disability and health-related quality of life (HrQoL), respectively. As they may measure partially overlapping constructs, we assessed their relationship.

methodsWe conducted a secondary analysis of the multicenter cluster-randomized controlled Enhanced Recovery after Intensive Care (ERIC) trial (ClinicalTrials.gov: NCT03671447). At follow-ups scheduled 6 months after ICU discharge, critical illness survivors and caregivers completed the EQ-5D-5L, the patient-reported and the proxy-reported 12-item WHODAS 2.0. We employed local polynomial regressions, correlation coefficients, and linear regressions to analyze the global and domain-specific relationships between the EQ-5D-5L and the WHODAS 2.0.

resultsWe analyzed 700 patients with a median EQ-5D-5L index value of 0.81 [IQR 0.52 to 0.94], a median patient-reported WHODAS 2.0 sum score of 11 [IQR 3 to 23], and a median proxy-reported WHODAS 2.0 sum score of 16 [IQR 6 to 28]. The EQ-5D-5L index value highly correlated with patient-reported (Spearman: - 0.84 [95% CI - 0.86 to - 0.82]) and proxy-reported (Spearman: - 0.70 [- 0.76 to - 0.64]) WHODAS 2.0 sum scores. Corresponding domains were also highly correlated, with the patient-reported WHODAS 2.0 aligning more closely with the EQ-5D-5L than the proxy-reported WHODAS 2.0. We found ceiling and floor effects for both instruments, indicating limitations for detecting mild disabilities and high HrQoL. In multivariable linear regressions, the patient-reported and proxy-reported WHODAS 2.0 sum scores (both - 0.02 [95% CI - 0.02 to - 0.02], p < 0.01) and WHODAS 2.0 domain scores for mobility, self-care, and life activities were predictors of the EQ-5D-5L index value and respective EQ-5D-5L domain scores.

conclusionsOur results suggest a high correlation between the patient-reported and proxy-reported WHODAS 2.0 and the EQ-5D-5L, particularly in their corresponding domains. To economize post-ICU assessments, there may be no need to use both instruments simultaneously.

Indexed as

Critical IllnessDisability EvaluationPersons with DisabilitiesProxyQuality of LifeSurvivorsAdultAgedFemaleHumansIntensive Care UnitsMaleMiddle AgedPatient Reported Outcome MeasuresPsychometricsSelf ReportCritical careDisabilityEQ-5D-5LHealth-related quality of lifePost-ICU carePost-intensive care syndromeWHODAS

Identifiers

PMID40270036
PMCPMC12020060

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.