ArticleCell & bioscience2025
Huddling behavior regulate adaptive thermogenesis in Brandt's voles (Lasiopodomys brandtii).
Article in Cell & bioscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Identification and Characterization of the Complete Genome of the TGF-International journal of molecular sciences · 2025Article
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4 authors.
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Abstract
backgroundBrown adipose tissue (BAT) is the main site of non-shivering thermogenesis (NST) in small mammals, playing an important role in maintaining body temperature and energy balance. Huddling is a behavioral strategy for small rodents to save energy and improve the survival under cold environments. However, the way of huddling behavior influence on hypothalamus, which regulate BAT thermogenesis in small mammals is rarely illustrated. We used male Brandt's voles (Lasiopodomys brandtii) to explore the possible regulation mechanisms in BAT thermogenesis by the way of cold acclimation and huddling behavior.
resultsThere is a strong relationship between huddling behavior and NST in BAT. The hypothalamus, which is impacted by huddling behavior, influences PPAR signaling pathway in the BAT, and induces thermogenesis through Calcium signaling pathway. PPAR pathway causes crosstalk among NF-κB signaling pathway, Thermogenesis and Fatty acid metabolism to perform functions for thermogenesis.
conclusionsThe results suggest that huddling behavior can modulate adaptive thermogenesis in BAT. Cold acclimation and huddling had a synergistic effect on the regulation of thermogenic function, the hypothalamus mediates thermogenic changes in BAT induced by huddling behavior. In BAT, the specific pathway of thermogenesis is as follows: TRAF6-PPARγ-UCP1-SUCLG1.
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