Evidence map›Paper›PMID 40269983›Full record

ArticleAntimicrobial resistance and infection control2025

Prevalence of fungi and their antifungal and disinfectant resistance in hospital environments: insights into combating nosocomial mycoses.

Soudabeh Ghodsi, Mahnaz Nikaeen, Shima Aboutalebian, Rasoul Mohammadi, Hossein Mirhendi

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Article in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

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0cells of the map it votes in
6citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

Soudabeh GhodsiDepartment of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Hezar Jrib Avenue, Isfahan, Iran.
Mahnaz NikaeenDepartment of Environmental Health Engineering, School of Health, Isfahan University of Medical Sciences, Hezar Jrib Avenue, Isfahan, Iran. nikaeen@hlth.mui.ac.ir.
Shima AboutalebianDepartment of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Rasoul MohammadiDepartment of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Hossein MirhendiDepartment of Medical Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.

Funding

Isfahan University of Medical Sciences 1400436
6 · The paper itself

Abstract

backgroundFungal infections are increasingly recognized as a global health concern, contributing to considerable morbidity and mortality in hospital settings. This underscores the urgent need for infection prevention and control in healthcare facilities to protect vulnerable patients from the risk of acquiring invasive fungal diseases (IFDs). Given the critical role of transmission-based precautions in limiting the spread of filamentous fungi responsible for IFDs, this study was conducted to explore the potential role of the hospital environment in the dissemination of these infections.

methodsA total of 83 samples were collected from the air and surface of exhaust vents in the intensive care units (ICUs) of hospitals in Isfahan, Iran, to assess the presence and diversity of fungal species. Susceptibility testing against antifungal agents, including commonly used drugs and disinfectants, was performed on the identified fungal isolates. Furthermore, the antifungal resistance profiles of isolates from clinical IFD cases were compared with those of environmental isolates.

resultsFungi were detected in 45% of air samples and 100% of exhaust vent samples, with Aspergillus species being the most commonly identified genus. Mucorales were also found in 17% of exhaust vent samples. Aspergillus spp. and Rhizopus spp. showed the highest resistance to Amphotericin B, and a considerable proportion of these isolates exhibited simultaneous resistance to disinfectants. A similar antifungal resistance profile was noted between A. flavus and some R. arrhizus isolates from both environmental and clinical samples.

conclusionsThe findings of this study indicate that the hospital environment, particularly exhaust vents, may act as a significant reservoir for causative agents of IFDs. This highlights the importance of environmental surveillance in preventing and controlling nosocomial fungal infections.

Indexed as

Antifungal AgentsCross InfectionDisinfectantsDrug Resistance, FungalFungiMycosesAir MicrobiologyAspergillusHospitalsHumansIntensive Care UnitsIranMicrobial Sensitivity TestsPrevalenceAntifungal AgentsDisinfectantsAirAntifungal drugsAspergillusDisinfectantsInvasive fungal diseasesMucorales

Identifiers

PMID40269983
PMCPMC12020322

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.