Evidence map›Paper›PMID 40269949›Full record

Trial reportHead & face medicine2025

Low intensity pulsed ultrasound versus low-level laser therapy on peri-implant marginal bone preservation and soft tissue healing following dental implant surgery: a randomized controlled trial.

Esraa S Mahmoud, Amal M Abd El-Baky, Osama M Gouda, Hussein G Hussein

Registry-linked trialAbstract readRandomized Controlled TrialComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Head & face medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05938868 (Efficacy of Low Intensity Pulsed Ultrasound and Low Level Laser Therapy on Osseointegration and Soft Tissue Healing Following Dental Implant Surgery), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05938868 nacompletednot on this map

Efficacy of Low Intensity Pulsed Ultrasound and Low Level Laser Therapy on Osseointegration and Soft Tissue Healing Following Dental Implant Surgery: a Randomized Controlled Trial

TypeinterventionalSponsorAhram Canadian UniversityRan2023 to 2024Enrolled63ConditionsDental Implant, Surgical Dental Prostheses, Dental ImplantationArmsLow intensity pulsed ultrasound (LIPUS), low level diode laser therapy, Standard Care
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Esraa S MahmoudDepartment of Physical Therapy for surgery & burn, Faculty of Physical Therapy, Al-Hayah University in Cairo, Universities & Schools hub, New Cairo 3, 5th Settlement, Cairo, Egypt. esraa.sabry@ahuc.edu.eg.ORCID http://orcid.org/0000-0002-4738-9098
Amal M Abd El-BakyDepartment of Physical Therapy for surgery, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.ORCID http://orcid.org/0009-0000-0741-4650
Osama M GoudaFaculty of Dentistry, Badr University, Cairo, Egypt.ORCID http://orcid.org/0009-0007-1791-1184
Hussein G HusseinDepartment of Physical Therapy for surgery, Faculty of Physical Therapy, Cairo University, Cairo, Egypt.ORCID http://orcid.org/0000-0001-7264-1489

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLow-intensity pulsed ultrasound (LIPUS) and low-level laser therapy (LLLT) are proposed adjunctive therapies to enhance healing after dental implant surgery. However, direct comparisons of their effects on peri-implant marginal bone preservation and soft tissue healing remain limited. This randomized controlled trial aimed to compare the effectiveness of LIPUS and LLLT on peri-implant marginal bone preservation, soft tissue healing, pain levels, and oral health-related quality of life following dental implant placement.

methodsThis single-blind, randomized controlled trial included 63 patients undergoing maxillary or mandibular implant placement, randomly allocated to LIPUS (n = 21), LLLT (n = 21), or control (n = 21) groups. LIPUS was applied twice weekly for 4 weeks, while LLLT was administered in 4 sessions over 2 weeks post-implant. Marginal bone loss (MBL) and OHRQoL (OHIP-14) were assessed at baseline, 6, and 12 weeks. Soft tissue healing (Landry Healing Index) and pain (VAS) were evaluated at baseline, 7-, 14-, 21-, and 30-days post-implant.

resultsLIPUS significantly reduced marginal bone loss at 6 weeks and 3 months post-implant compared to LLLT and control groups (p < 0.05). LLLT demonstrated superior soft tissue healing at 7-, 14-, 21-, and 30-days post-implant (p < 0.05). Both interventions significantly decreased pain intensity and improved OHRQoL at various time points compared to the control group (p < 0.05).

conclusionsLIPUS and LLLT significantly enhance peri-implant marginal bone preservation, soft tissue healing, pain management, and OHRQoL in dental implant patients compared to standard care. LIPUS was more effective for peri-implant marginal bone preservation, while LLLT excelled in soft tissue healing.

trial registrationThis study was registered at ClinicalTrials.gov (NCT05938868) on July 11, 2023.

Indexed as

Alveolar Bone LossDental ImplantationDental ImplantsLow-Level Light TherapyUltrasonic TherapyWound HealingAdultAgedFemaleHumansMaleMiddle AgedQuality of LifeSingle-Blind MethodTreatment OutcomeDental ImplantsDental implantsLow-intensity pulsed ultrasoundLow-level laser therapyOral health-related quality of lifeOsseointegrationPainSoft tissue healing

Identifiers

PMID40269949
PMCPMC12016225

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.