ArticleLipids in health and disease2025
Association between the combination of the triglyceride-glucose index and obesity-related indices with hyperuricemia among children and adolescents in China.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The association between the triglyceride-glucose index and serum uric acid: a systematic review and meta-analysis.BMC endocrine disorders · 2026Pooled it
- Clinical Determinants of Serum Uric Acid Levels in Patients with Obesity and Hypertension.Journal of clinical medicine · 2026Article
- Screening for insulin resistance in children with abdominal obesity: sex-specific performance of TyG index, FGIR, and VAI.Physical activity and nutrition · 2026Article
- Associations of the triglyceride-glucose index, triglyceride glucose-body mass index, waist-triglyceride index and modified triglyceride-glucose indices with mortality in cardiovascular-kidney-metabolic syndrome stages 0-4: Evidence from NHANES 1999-2020.Journal of translational internal medicine · 2026Article
- Retinol Binding Protein 4 and Uric Acid as Risk Factors for Insulin Resistance in Type 2 Diabetes Mellitus.Journal of diabetes research · 2026Article
- The relationship between secondhand smoke exposure in Chinese children and adolescents and renal function and hyperuricemia: a cross-sectional study.Frontiers in pediatrics · 2026Article
- Article
- Association between the triglyceride-glucose index and hyperuricemia in patients with type 2 diabetes mellitus.Frontiers in endocrinology · 2025Article
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12 authors.
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Abstract
backgroundThe prevalence of hyperuricemia (HUA) among Chinese children and adolescents is a significant public health concern. Triglyceride-glucose (TyG) is recognized as a reliable biomarker in predicting insulin resistance, a condition associated with various metabolic disorders. Nevertheless, research on the association between TyG and its obesity-related indices with HUA among children and adolescents in China is limited.
methodsThis study utilized data from the 2017 Chinese National Nutrition and Health Surveillance of Children and Lactating Mothers. TyG, TyG-BMI, TyG-WC, and TyG-WHtR were calculated based on participants' fasting blood glucose, triglycerides, and measured height, weight, and waist circumference. Multivariable logistic regressions were used to assess the relationships between TyG and its obesity-related indices with HUA in children and adolescents. Receiver Operating Characteristic curves were constructed to compare the predictive power of these indicators. Furthermore, we conducted a stratified analysis based on sex and age. Restricted cubic spline curves were used to illustrate the dose-response relationship of TyG, TyG-BMI, TyG-WC, and TyG-WHtR with HUA in children and adolescents. The sensitivity analysis included 1:1 propensity score matching with a caliper value of 0.02 and adjustments to the diagnostic criteria for HUA.
resultsAfter adjusting for all covariables, multivariable logistic regression analysis indicated that the fourth quartiles of TyG (OR: 1.33, 95% CI: 1.14-1.54, P < 0.001), TyG-BMI (OR: 1.43, 95% CI: 1.14-1.79, P = 0.002), TyG-WC (OR: 1.76, 95% CI: 1.42-2.19, P < 0.001), and TyG-WHtR (OR: 1.92, 95% CI: 1.66-2.21, P < 0.001) were significantly associated with higher odds of HUA, compared to the lowest quartile. Stratified analyses identified a significant interaction between sex and TyG-BMI, TyG-WC, and TyG-WHtR. Compared to the first quartile, the highest quartile of TyG-BMI, TyG-WC and TyG-WHtR among male participants exhibited a stronger association with HUA(Male: TyG-BMI: OR = 1.82, 95%CI: 1.28-2.59; TyG-WC: OR = 1.87, 95%CI: 1.31-2.67; TyG-WHtR: OR = 2.07, 95%CI: 1.68-2.54).
conclusionsThis study identified a significant association between TyG and related obesity indices with HUA in children and adolescents in China. Furthermore, stronger associations of TyG-BMI, TyG-WC, and TyG-WHtR with HUA were observed, particularly in males.
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