ArticleLipids in health and disease2025
Association between triglyceride-glucose index in early pregnancy and risk of preeclampsia: a multicenter retrospective cohort study.
Article in Lipids in health and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The correlation between triglyceride-glucose index in early pregnancy (<20 weeks) and pregnancy complications and adverse pregnancy outcomes: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Ultrasound-derived fat fraction and automated point shear-wave elastography in diagnosing intrahepatic cholestasis of pregnancy and preeclampsia.BMC pregnancy and childbirth · 2026Article
- Distinct pregnancy challenges in PCOS women undergoing IVF/ICSI with singleton and twin births: a propensity-matched analysis.Journal of ovarian research · 2026Article
- TyHGB as a predictive marker for preeclampsia: association with increased risk in pregnant women with normal glucose tolerance.Lipids in health and disease · 2026Article
- Association of late-pregnancy triglyceride-glucose index and growth differentiation factor 15 with adverse pregnancy outcomes in women with gestational diabetes mellitus.BMC pregnancy and childbirth · 2026Article
- Elevated serum uric acid before 20 weeks of gestation increases the risk of preeclampsia.Scientific reports · 2026Article
- Association between atherogenic index of plasma in early pregnancy and risk of preeclampsia: a multicenter cohort study.Frontiers in nutrition · 2026Article
- Association between triglyceride-glucose index, placental inflammatory cytokines, and perinatal outcomes in preeclampsia.Frontiers in endocrinology · 2026Article
- CRP-triglyceride-glucose index (CTGI) as a predictor of preeclampsia: a population-based study of risk stratification.Lipids in health and disease · 2025Article
- First-trimester atherogenic index of plasma and triglyceride-glucose indices in pregestational diabetes mellitus: associations with adverse pregnancy outcomes.BMC pregnancy and childbirth · 2025Article
- Association of metabolic score for insulin resistance and preeclampsia: a multicenter cohort study.Lipids in health and disease · 2025Article
- Dynamic TyG-inflammation-endothelial trajectories and placental histopathology synergistically define a maternal-fetal vascular risk phenotype.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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Abstract
backgroundPrevious evidence has indicated that insulin resistance may be an early pathological state of preeclampsia (PE). As a novel biomarker, the triglyceride glucose (TyG) index can reflect the level of insulin resistance in the body. The present study aimed to investigate the association between the TyG index and risk of PE.
methodsThis study included 41,694 singleton pregnant women, comprising 2,308 PE patients and 39,386 healthy controls from three tertiary hospitals from January 2019 to June 2024. Datas were retrospectively collected via medical record review. The TyG index was measured before 20 weeks of gestation, and participants were grouped via the TyG index quartiles. The primary outcome was PE, and the secondary outcomes were preterm birth and low birth weight (LBW). Multivariable logistic regression was used to calculate the odds ratios (ORs) for the TyG index quartiles compared to the lowest quartile for the primary and secondary outcomes. Subgroup analyses were conducted to evaluate the effect of age, body mass index (BMI), parity and TyG test week on these associations. The predictive efficacy of the TyG index for PE was assessed using receiver operating characteristic (ROC) curve analysis.
resultsAfter adjusting for confounders, compared to TyG index Q1, a higher TyG index was positively associated with PE (TyG index Q3 OR = 1.23, 95% confidence interval (CI): 1.06-1.43, P = 0.0067; TyG index Q4 OR = 1.31, 95% CI: 1.11-1.53, P = 0.0011) and preterm birth (TyG index Q4 OR = 1.18, 95% CI: 1.01-1.37, P = 0.0376), negatively associated with LBW (TyG index Q3 OR = 0.84, 95% CI: 0.74-0.97, P = 0.0147). In Model I, a significant association was observed between higher TyG quartiles and preterm birth (P = 0.0472 for Q3 and P = 0.0000 for Q4), but this association was not significant in Model II after adjusting for confounders. Subgroup analyses revealed that age, pre-pregnancy BMI, parity and test week did not influence these associations (interaction P > 0.05). The area under the ROC curve (AUC) for the predictive model was 0.596 (95% CI: 0.584-0.608), with a sensitivity of 65.4% and a specificity of 49.6%.
conclusionThe present findings suggested that the TyG index associated with a high risk of PE. Clinical evaluation incorporating the TyG index during early pregnancy may help in screening for patients at high risk of PE.
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