Evidence map›Paper›PMID 40269818›Full record

ArticleBMC neurology2025

Global, regional and national burden of Parkinson's disease in people over 55 years of age: a systematic analysis of the global burden of disease study, 1991-2021.

Shaoyi Peng, Peng Liu, Xiaowen Wang, Kaiyuan Li

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Article in BMC neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  8. [Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2026
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  12. Temperature fluctuations and genetic influences on Parkinson's disease: a comprehensive analysis of temperature variability and time spent outdoors in the United States (1999-2023).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Shaoyi Peng *Department of Cardiology, The First People's Hospital of Jiande, Hangzhou, China.
Peng Liu *Department of Cardiology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Xiaowen Wang *Department of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China.
Kaiyuan LiDepartment of Cardiology, The Affiliated Taizhou People's Hospital of Nanjing Medical University, Taizhou, China. 986970919@qq.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundParkinson's disease (PD) has emerged as a major global public health challenge. However, there is currently a lack of systematic analysis regarding the burden of PD and its long-term trends among people over 55 years of age.

methodsThis study utilizes data from the Global Burden of Disease 2021 database to analyze the prevalence, incidence, disability-adjusted life years (DALYs), and mortality rates of PD in individuals aged 55 and older from 1990 to 2021. The annual percentage change was calculated to assess the temporal trends of the disease burden. Point estimates and their corresponding ranges were reported with 95% uncertainty intervals.

resultsGlobally, the prevalence, incidence, DALYs, and mortality rates of PD in individuals aged 55 and above significantly increased from 1990 to 2021, with all indicators being higher in males than in females. This trend was evident across all five Socio-Demographic Index (SDI) groups and in 21 regions worldwide. The number of prevalent cases, incident cases, DALYs, and deaths all showed significant increases and were positively correlated with SDI (R = 0.645, P < 0.001). Among 185 countries, the incidence rate increased, with DALY rates rising in 74 countries and mortality rates rising in 65 countries. Notably, in the population aged 95 years and older, the prevalence and incidence of PD showed particularly remarkable increases, at 735% and 505%, respectively. Furthermore, the greatest increase in prevalence was observed in the 55-59 age group, especially in countries with Middle SDI and High-middle SDI regions.

conclusionsThis study indicates that the burden of PD in individuals aged 55 and above has significantly increased over the past three decades. This trend reflects the profound impact of global aging and socioeconomic development levels on the burden of PD, underscoring the urgency of addressing PD as a major global public health challenge.

Indexed as

Global Burden of DiseaseParkinson DiseaseAgedAged, 80 and overCost of IllnessDisability-Adjusted Life YearsFemaleGlobal HealthHumansIncidenceMaleMiddle AgedPrevalenceEpidemiological trendsGlobal burden of diseaseMiddle-aged and elderly populationsParkinson's diseaseSocio-demographic index

Identifiers

PMID40269818
PMCPMC12016353

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.